Gene Information
Gene NameTXBP181
OrganismHomo sapiens (Human)
Gene Length718
Protein NamesMitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBQ9Y6D9
Gene CardMAD1L1
Uniprot IDQ9Y6D9
PfamPF05557
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue Specificity[Isoform 1]: Expressed in hepatocellular carcinomas and hepatoma cell lines (at protein level). {ECO:0000269|PubMed:19010891, ECO:0000269|PubMed:24374861}.;
[Isoform 3]: Expressed in hepatocellular carcinomas and hepatoma cell lines (at protein level). {ECO:0000269|PubMed:19010891}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1GO4  (X-ray  2.05A  )  4DZO  (X-ray  1.76A  )  7B1F  (X-ray  1.75A  )  7B1H  (X-ray  2.40A  )  7B1J  (X-ray  2.90A  ) 
DBSNP rs121908982  rs550573452  rs769418574  rs193231481  rs377555260  rs371561369  rs755012008  rs1801368  rs201951163  rs1801500 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:19010891, ECO:0000269|PubMed:9546394}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:14978040, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:22351768, ECO:0000269|PubMed:29162720}. Nucleus envelope {ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:22351768}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14978040, ECO:0000269|PubMed:9546394}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:9546394}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:22351768}. Note=Co-localizes with TPR at the nucleus envelope during interphase and throughout the cell cycle (PubMed:22351768, PubMed:18981471). From the beginning to the end of mitosis, it is seen to move from a diffusely nuclear distribution to the centrosome, to the spindle midzone and finally to the midbody (PubMed:9546394). Localizes to kinetochores during prometaphase (PubMed:22351768, PubMed:29162720). Does not localize to kinetochores during metaphase (PubMed:29162720). Colocalizes with NEK2 at the kinetochore (PubMed:14978040). Colocalizes with IK at spindle poles during metaphase and anaphase (PubMed:22351768). {ECO:0000269|PubMed:14978040, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:22351768, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:9546394}.;
[Isoform 3]: Cytoplasm {ECO:0000269|PubMed:19010891}.
Mouse PG classificationNA
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