| Gene Information | |
|---|---|
| Gene Name | CLDN10 |
| Organism | Homo sapiens (Human) |
| Gene Length | 228 |
| Protein Names | Claudin-10 (Oligodendrocyte-specific protein-like) (OSP-like) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000134873 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P78369 |
| Gene Card | CLDN10 |
| Uniprot ID | P78369 |
| Pfam | PF00822 |
| In ASD | no |
| Allosteric Prediction | no (-0.998643259) |
| Ortholog in Animals | Alpaca_ CLDN10 ( ortholog_one2one ) Dog_ CLDN10 ( ortholog_one2one ) GuineaPig_ CLDN10 ( ortholog_one2one ) Macaque_ CLDN10 ( ortholog_one2one ) Mouse_ Cldn10 ( ortholog_one2one ) Pig_ CLDN10 ( ortholog_one2one ) Rat_ Cldn10 ( ortholog_one2one ) Rabbit_ CLDN10 ( ortholog_one2one ) |
| Ohnologs | CLDN7, CLDN18, CLDN1 |
| Paralogs | CLDN1, CLDN5, CLDN8, CLDN3, CLDN20, CLDN11, CLDN14, CLDN18, CLDN7, CLDN9, CLDN17, CLDN24, CLDN22, CLDN23, CLDN4, CLDN15, CLDN19, CLDN34, CLDN2, CLDN25, CLDN16, CLDN6 |
| Tissue | brain, kidney, liver, lung, pancreas |
| Tissue Specificity | Expressed in the kidney, eccrine sweat glands and in all layers of the epidermis. In the kidney, it is detected in the thick ascending limb of Henle's loop (TAL) (PubMed:28771254, PubMed:28686597). In the sweat glands, it is expressed in cells from secretory portions, corresponding to the clear cells (PubMed:28686597). {ECO:0000269|PubMed:28686597, ECO:0000269|PubMed:28771254}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs759408749 rs1555299783 |
| Subcellular location [CC] | Cell junction, tight junction {ECO:0000269|PubMed:19383724}. Cell membrane {ECO:0000269|PubMed:19383724, ECO:0000269|PubMed:28686597, ECO:0000269|PubMed:28771254}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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