| Gene Information | |
|---|---|
| Gene Name | TUFT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 390 |
| Protein Names | Tuftelin |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000143367 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9NNX1 |
| Gene Card | TUFT1 |
| Uniprot ID | Q9NNX1 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.21774989) |
| Ortholog in Animals | Alpaca_ TUFT1 ( ortholog_one2one ) Dog_ TUFT1 ( ortholog_one2one ) GuineaPig_ TUFT1 ( ortholog_one2one ) Macaque_ TUFT1 ( ortholog_one2one ) Mouse_ Tuft1 ( ortholog_one2one ) Pig_ TUFT1 ( ortholog_one2one ) Rat_ Tuft1 ( ortholog_one2one ) Rabbit_ TUFT1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MYZAP, CCDC68, POLR2M |
| Tissue | NA |
| Tissue Specificity | Present in the extracellular enamel and is mainly associated with the crystal component. {ECO:0000269|PubMed:1874744}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs3828054 rs16833395 |
| Subcellular location [CC] | Secreted {ECO:0000250|UniProtKB:P27628}. Note=Secreted at a very early stage of enamel formation, concentrated at the dentin-enamel junction and tightly bound to the surface of the growing crystallites. {ECO:0000250|UniProtKB:P27628}. |
| Mouse PG classification | NA |
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