| Gene Information | |
|---|---|
| Gene Name | HDAC5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1122 |
| Protein Names | Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9) |
| Target Name | histone deacetylase |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000108840 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9UQL6 |
| Gene Card | HDAC5 |
| Uniprot ID | Q9UQL6 |
| Pfam | PF12203; PF00850 |
| In ASD | no |
| Allosteric Prediction | yes (0.71846972) |
| Ortholog in Animals | Alpaca_ HDAC5 ( ortholog_one2one ) Dog_ HDAC5 ( ortholog_one2one ) GuineaPig_ HDAC5 ( ortholog_one2one ) Macaque_ HDAC5 ( ortholog_one2one ) Mouse_ Hdac5 ( ortholog_one2one ) Pig_ HDAC5 ( ortholog_one2one ) Rat_ Hdac5 ( ortholog_one2one ) Rabbit_ HDAC5 ( ortholog_one2one ) |
| Ohnologs | HDAC9, HDAC7, HDAC4 |
| Paralogs | HDAC4, HDAC11, HDAC8, HDAC3, HDAC7, HDAC6, HDAC10, HDAC2, HDAC1, HDAC9 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.021739(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5UWI (X-ray 2.14A ) |
| DBSNP | rs438096 rs33916560 |
| Subcellular location [CC] | Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-259 and Ser-498 by AMPK, CaMK1 and SIK1. |
| Mouse PG classification | NA |
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