| Gene Information | |
|---|---|
| Gene Name | TUBB4A |
| Organism | Homo sapiens (Human) |
| Gene Length | 444 |
| Protein Names | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) |
| Target Name | tubulin beta-4a chain |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000104833 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P04350 |
| Gene Card | TUBB4A |
| Uniprot ID | P04350 |
| Pfam | PF00091; PF03953 |
| In ASD | no |
| Allosteric Prediction | yes (0.142496819) |
| Ortholog in Animals | Alpaca_ TUBB4A ( ortholog_one2one ) Dog_ TUBB4A ( ortholog_one2one ) GuineaPig_ TUBB4A ( ortholog_one2one ) Macaque_ TUBB4A ( ortholog_one2one ) Mouse_ Tubb4a ( ortholog_one2one ) Pig_ TUBB4A ( ortholog_one2one ) Rat_ Tubb4a ( ortholog_one2one ) Rabbit_ TUBB4A ( ortholog_one2one ) |
| Ohnologs | TUBB4B |
| Paralogs | TUBB, TUBA4B, TUBA8, TUBA4A, TUBB6, TUBB3, TUBAL3, TUBG2, TUBB8, TUBB8B, TUBE1, TUBB1, TUBB4B, TUBA1B, TUBA1A, TUBA1C, TUBA3E, TUBA3C, TUBA3D, TUBD1, TUBG1, TUBB2A, TUBB2B |
| Tissue | brain, cerebral.cortex |
| Tissue Specificity | Major isotype in brain, where it represents 46% of all beta-tubulins. In the brain, highest expression levels in the cerebellum, followed by putamen and white matter. Moderate levels in testis. Very low levels, if any, in other tissues. {ECO:0000269|PubMed:20191564, ECO:0000269|PubMed:23424103}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs587776983 rs1053262 rs483352809 rs1053267 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton. |
| Mouse PG classification | NA |
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