| Gene Information | |
|---|---|
| Gene Name | TUBB |
| Organism | Homo sapiens (Human) |
| Gene Length | 444 |
| Protein Names | Tubulin beta chain (Tubulin beta-5 chain) |
| Target Name | tubulin beta chain |
| Target Type | NA |
| Gene Age | 3 ( ENSG00000183311 ) 544 ( ENSG00000196230 ) 3 ( ENSG00000224156 ) 3 ( ENSG00000227739 ) 3 ( ENSG00000229684 ) 3 ( ENSG00000232421 ) 3 ( ENSG00000232575 ) 3 ( ENSG00000235067 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P07437 |
| Gene Card | TUBB |
| Uniprot ID | P07437 |
| Pfam | PF00091; PF03953 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999942399) |
| Ortholog in Animals | Alpaca_ TUBB ( ortholog_one2one ) Dog_ TUBB ( ortholog_one2one ) GuineaPig_ TUBB ( ortholog_one2one ) Macaque_ TUBB ( ortholog_one2one ) Mouse_ Tubb5 ( ortholog_one2one ) Pig_ TUBB ( ortholog_one2one ) Rat_ Tubb5 ( ortholog_one2one ) Rabbit_ TUBB ( ortholog_one2one ) |
| Ohnologs | TUBB4B |
| Paralogs | TUBA4B, TUBA8, TUBA4A, TUBB6, TUBB3, TUBAL3, TUBG2, TUBB8, TUBB8B, TUBE1, TUBB1, TUBB4B, TUBB4A, TUBA1B, TUBA1A, TUBA1C, TUBA3E, TUBA3C, TUBA3D, TUBD1, TUBG1, TUBB2A, TUBB2B |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed with highest levels in spleen, thymus and immature brain. {ECO:0000269|PubMed:20191564}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.017021(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 3QNZ (X-ray 2.20A ) 3QO0 (X-ray 2.30A ) 5N5N (EM 4.00A ) 6I2I (EM 3.60A ) 6QUS (EM 3.70A ) 6QUY (EM 3.80A ) 6QVE (EM 3.70A ) 6QVJ (EM 3.80A ) |
| DBSNP | rs864321676 rs864321677 rs587777355 rs587777356 rs587777357 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:26637975}. |
| Mouse PG classification | NA |
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