| Gene Information | |
|---|---|
| Gene Name | SPINK5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1064 |
| Protein Names | Serine protease inhibitor Kazal-type 5 (Lympho-epithelial Kazal-type-related inhibitor) (LEKTI) [Cleaved into: Hemofiltrate peptide HF6478; Hemofiltrate peptide HF7665] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 244 ( ENSG00000133710 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q9NQ38 |
| Gene Card | SPINK5 |
| Uniprot ID | Q9NQ38 |
| Pfam | PF00050 |
| In ASD | no |
| Allosteric Prediction | no (-0.709927729) |
| Ortholog in Animals | Alpaca_ SPINK5 ( ortholog_one2one ) Dog_ SPINK5 ( ortholog_one2one ) GuineaPig_ SPINK5 ( ortholog_one2one ) Macaque_ SPINK5 ( ortholog_one2one ) Mouse_ Spink5 ( ortholog_one2one ) Pig_ SPINK5 ( ortholog_one2one ) Rat_ Spink5 ( ortholog_one2one ) Rabbit_ SPINK5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | FSTL3, SPINK6, FSTL1, FSTL5, FSTL4, FST |
| Tissue | esophagus, esophagus.mucosa |
| Tissue Specificity | Highly expressed in the thymus and stratum corneum. Also found in the oral mucosa, parathyroid gland, Bartholin's glands, tonsils, and vaginal epithelium. Very low levels are detected in lung, kidney, and prostate. {ECO:0000269|PubMed:10419450}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1H0Z (NMR - ) 1HDL (NMR - ) 1UUC (NMR - ) 1UVF (NMR - ) 1UVG (NMR - ) 5YHN (NMR - ) |
| DBSNP | rs6892205 rs34482796 rs2303063 rs2303064 rs17775319 rs2303067 rs34393923 rs35877540 rs3777134 rs2303070 rs28408445 rs3188691 rs17705005 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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