| Gene Information | |
|---|---|
| Gene Name | MGLL |
| Organism | Homo sapiens (Human) |
| Gene Length | 303 |
| Protein Names | Monoglyceride lipase (MGL) (EC 3.1.1.23) (HU-K5) (Lysophospholipase homolog) (Lysophospholipase-like) (Monoacylglycerol lipase) (MAGL) |
| Target Name | monoglyceride lipase |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000074416 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q99685 |
| Gene Card | MGLL |
| Uniprot ID | Q99685 |
| Pfam | PF12146 |
| In ASD | yes |
| Allosteric Prediction | no (-0.029388035) |
| Ortholog in Animals | Alpaca_ MGLL ( ortholog_one2one ) Dog_ MGLL ( ortholog_one2one ) GuineaPig_ MGLL ( ortholog_one2one ) Macaque_ MGLL ( ortholog_one2one ) Mouse_ Mgll ( ortholog_one2one ) Pig_ MGLL ( ortholog_one2one ) Rat_ Mgll ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected in adipose tissue, lung, liver, kidney, brain and heart. {ECO:0000269|PubMed:11470505}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3HJU (X-ray 2.20A ) 3JW8 (X-ray 2.10A ) 3JWE (X-ray 2.70A ) 3PE6 (X-ray 1.35A ) 4UUQ (X-ray 2.36A ) 5ZUN (X-ray 1.35A ) 6AX1 (X-ray 2.26A ) 6BQ0 (X-ray 2.00A ) 7L4T (X-ray 2.20A ) 7L4U (X-ray 2.25A ) 7L4W (X-ray 2.20A ) 7L50 (X-ray 2.30A ) 7PRM (X-ray 1.65A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000250|UniProtKB:O35678}. Membrane {ECO:0000250|UniProtKB:O35678}; Peripheral membrane protein {ECO:0000250|UniProtKB:O35678}. |
| Mouse PG classification | NA |
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