| Gene Information | |
|---|---|
| Gene Name | TUBA1A |
| Organism | Homo sapiens (Human) |
| Gene Length | 451 |
| Protein Names | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] |
| Target Name | tubulin alpha-1a chain |
| Target Type | NA |
| Gene Age | 55 ( ENSG00000167552 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q71U36 |
| Gene Card | TUBA1A |
| Uniprot ID | Q71U36 |
| Pfam | PF00091; PF03953 |
| In ASD | yes |
| Allosteric Prediction | yes (0.99998543) |
| Ortholog in Animals | Alpaca_ TUBA1A ( ortholog_one2one ) Macaque_ TUBA1B ( ortholog_one2one ) Mouse_ Tuba1a ( ortholog_one2one ) Pig_ TUBA1A ( ortholog_one2one ) |
| Ohnologs | TUBA4A |
| Paralogs | TUBA1B, TUBA1C, TUBA3E, TUBA3C, TUBA3D, TUBB, TUBA4B, TUBA8, TUBA4A, TUBB6, TUBB3, TUBAL3, TUBG2, TUBB8, TUBB8B, TUBE1, TUBB1, TUBB4B, TUBB4A, TUBD1, TUBG1, TUBB2A, TUBB2B |
| Tissue | NA |
| Tissue Specificity | Expressed at a high level in fetal brain. {ECO:0000269|PubMed:17584854}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5JCO (EM 4.00A ) 6J8F (X-ray 2.28A ) 6WSL (EM 3.10A ) 7C1M (NMR - ) |
| DBSNP | rs137853045 rs137853046 rs137853043 rs587784483 rs137853044 rs137853044 rs137853047 rs1065730 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton. |
| Mouse PG classification | HPG |
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