| Gene Information | |
|---|---|
| Gene Name | TUB |
| Organism | Homo sapiens (Human) |
| Gene Length | 506 |
| Protein Names | Tubby protein homolog |
| Target Name | tubby protein homolog |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000166402 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P50607 |
| Gene Card | TUB |
| Uniprot ID | P50607 |
| Pfam | PF01167; PF16322 |
| In ASD | no |
| Allosteric Prediction | yes (0.360907253) |
| Ortholog in Animals | Alpaca_ TUB ( ortholog_one2one ) Dog_ TUB ( ortholog_one2one ) GuineaPig_ TUB ( ortholog_one2one ) Macaque_ TUB ( ortholog_one2one ) Mouse_ Tub ( ortholog_one2one ) Pig_ TUB ( ortholog_one2one ) Rat_ Tub ( ortholog_one2one ) Rabbit_ TUB ( ortholog_one2one ) |
| Ohnologs | TULP3, TULP2, TULP1 |
| Paralogs | TULP2, WDR35, TULP3, TULP1, TULP4 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1S31 (X-ray 2.70A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Secreted {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Binds phospholipid and is anchored to the plasma membrane through binding phosphatidylinositol 4,5-bisphosphate. Is released upon activation of phospholipase C. Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha. Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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