| Gene Information | |
|---|---|
| Gene Name | VPS35 |
| Organism | Homo sapiens (Human) |
| Gene Length | 796 |
| Protein Names | Vacuolar protein sorting-associated protein 35 (hVPS35) (Maternal-embryonic 3) (Vesicle protein sorting 35) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000069329 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96QK1 |
| Gene Card | VPS35 |
| Uniprot ID | Q96QK1 |
| Pfam | PF03635 |
| In ASD | no |
| Allosteric Prediction | no (-0.449015348) |
| Ortholog in Animals | Alpaca_ VPS35 ( ortholog_one2one ) Dog_ VPS35 ( ortholog_one2one ) GuineaPig_ VPS35 ( ortholog_one2one ) Macaque_ VPS35 ( ortholog_one2one ) Mouse_ Vps35 ( ortholog_one2one ) Pig_ VPS35 ( ortholog_one2one ) Rat_ Vps35 ( ortholog_one2one ) Rabbit_ VPS35 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Highly expressed in heart, brain, placenta, skeletal muscle, spleen, thymus, testis, ovary, small intestine, kidney and colon. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.031843(Rat);0.041905(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2R17 (X-ray 2.80A ) 5F0J (X-ray 2.70A ) 5F0K (X-ray 3.07A ) 5F0L (X-ray 3.20A ) 5F0M (X-ray 3.10A ) 5F0P (X-ray 2.78A ) 5OSH (X-ray 4.30A ) 5OSI (X-ray 2.52A ) 7BLN (EM 8.90A ) 7BLO (EM 9.50A ) |
| DBSNP | rs193077277 rs183554824 rs188245364 rs192783364 rs770029606 rs184277092 rs34687100 rs188286943 rs749516404 rs192419029 |
| Subcellular location [CC] | Cytoplasm. Membrane; Peripheral membrane protein. Endosome {ECO:0000269|PubMed:15078903, ECO:0000269|PubMed:28892079}. Early endosome {ECO:0000305}. Late endosome {ECO:0000305}. Note=Localizes to tubular profiles adjacent to endosomes. {ECO:0000269|PubMed:15078903}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |