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Gene Information
Gene Name
TTR
Organism
Homo sapiens (Human)
Gene Length
147
Protein Names
Transthyretin (ATTR) (Prealbumin) (TBPA)
Target Name
transthyretin
Target Type
Successful target
Gene Age
544 ( ENSG00000118271 )
Evolutionary Stage
Vertebrata
AlphaFoldDB
P02766
Gene Card
TTR
Uniprot ID
P02766
Pfam
PF00576
In ASD
yes
Allosteric Prediction
yes (1.000043149)
Ortholog in Animals
Alpaca_ TTR ( ortholog_one2one )
Dog_ TTR ( ortholog_one2one )
GuineaPig_ TTR ( ortholog_one2one )
Macaque_ TTR ( ortholog_one2one )
Mouse_ Ttr ( ortholog_one2one )
Pig_ TTR ( ortholog_one2one )
Rat_ Ttr ( ortholog_one2one )
Rabbit_ TTR ( ortholog_one2one )
Ohnologs
NA
Paralogs
URAD
Tissue
liver, pancreas
Tissue Specificity
Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver. {ECO:0000269|PubMed:10328977, ECO:0000269|PubMed:3714052}.
Pharmacological Animal Models
NULL(Chimpanzee);0.001000(Mouse);0.001000(Rat);0.050000(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
1BM7
(X-ray
2.00A
)
1BMZ
(X-ray
2.00A
)
1BZ8
(X-ray
2.00A
)
1BZD
(X-ray
1.90A
)
1BZE
(X-ray
1.80A
)
1DVQ
(X-ray
2.00A
)
1DVS
(X-ray
2.00A
)
1DVT
(X-ray
1.90A
)
1DVU
(X-ray
1.90A
)
1DVX
(X-ray
2.00A
)
1DVY
(X-ray
1.90A
)
1DVZ
(X-ray
1.90A
)
1E3F
(X-ray
1.90A
)
1E4H
(X-ray
1.80A
)
1E5A
(X-ray
1.80A
)
1ETA
(X-ray
1.70A
)
1ETB
(X-ray
1.70A
)
1F41
(X-ray
1.30A
)
1F86
(X-ray
1.10A
)
1FH2
(X-ray
1.80A
)
1FHN
(X-ray
1.75A
)
1G1O
(X-ray
2.30A
)
1GKO
(X-ray
2.10A
)
1ICT
(X-ray
3.00A
)
1III
(X-ray
2.00A
)
1IIK
(X-ray
2.00A
)
1IJN
(X-ray
1.70A
)
1QAB
(X-ray
3.20A
)
1QWH
(X-ray
1.36A
)
1RLB
(X-ray
3.10A
)
1SOK
(X-ray
1.60A
)
1SOQ
(X-ray
2.10A
)
1THA
(X-ray
2.00A
)
1THC
(X-ray
2.30A
)
1TLM
(X-ray
1.90A
)
1TSH
(X-ray
1.70A
)
1TT6
(X-ray
1.80A
)
1TTA
(X-ray
1.70A
)
1TTB
(X-ray
1.70A
)
1TTC
(X-ray
1.70A
)
1TTR
(X-ray
1.90A
)
1TYR
(X-ray
1.80A
)
1TZ8
(X-ray
1.85A
)
1U21
(X-ray
1.69A
)
1X7S
(X-ray
1.55A
)
1X7T
(X-ray
1.60A
)
1Y1D
(X-ray
1.70A
)
1Z7J
(X-ray
2.20A
)
1ZCR
(X-ray
1.80A
)
1ZD6
(X-ray
1.90A
)
2B14
(X-ray
2.00A
)
2B15
(X-ray
1.70A
)
2B16
(X-ray
1.75A
)
2B77
(X-ray
1.70A
)
2B9A
(X-ray
1.54A
)
2F7I
(X-ray
1.60A
)
2F8I
(X-ray
1.54A
)
2FBR
(X-ray
1.46A
)
2FLM
(X-ray
1.65A
)
2G3X
(X-ray
1.58A
)
2G3Z
(X-ray
1.90A
)
2G4E
(X-ray
2.17A
)
2G4G
(X-ray
1.85A
)
2G5U
(X-ray
1.80A
)
2G9K
(X-ray
1.85A
)
2GAB
(X-ray
1.85A
)
2H4E
(X-ray
1.45A
)
2M5N
(NMR
-
)
2NBO
(NMR
-
)
2NBP
(NMR
-
)
2NOY
(X-ray
1.80A
)
2PAB
(X-ray
1.80A
)
2QEL
(X-ray
2.29A
)
2QGB
(X-ray
1.40A
)
2QGC
(X-ray
1.30A
)
2QGD
(X-ray
1.50A
)
2QGE
(X-ray
1.45A
)
2ROX
(X-ray
2.00A
)
2ROY
(X-ray
2.20A
)
2TRH
(X-ray
1.90A
)
2TRY
(X-ray
2.00A
)
2WQA
(X-ray
2.85A
)
3A4D
(X-ray
2.00A
)
3A4E
(X-ray
1.70A
)
3A4F
(X-ray
1.99A
)
3B56
(X-ray
1.55A
)
3BSZ
(X-ray
3.38A
)
3BT0
(X-ray
1.59A
)
3CBR
(X-ray
1.70A
)
3CFM
(X-ray
1.60A
)
3CFN
(X-ray
1.87A
)
3CFQ
(X-ray
2.09A
)
3CFT
(X-ray
1.87A
)
3CN0
(X-ray
1.52A
)
3CN1
(X-ray
1.52A
)
3CN2
(X-ray
1.52A
)
3CN3
(X-ray
1.80A
)
3CN4
(X-ray
1.40A
)
3CXF
(X-ray
2.30A
)
3D2T
(X-ray
1.85A
)
3D7P
(X-ray
1.72A
)
3DGD
(X-ray
1.38A
)
3DID
(X-ray
1.78A
)
3DJR
(X-ray
2.02A
)
3DJS
(X-ray
1.80A
)
3DJT
(X-ray
2.30A
)
3DJZ
(X-ray
1.82A
)
3DK0
(X-ray
1.87A
)
3DK2
(X-ray
2.35A
)
3DO4
(X-ray
2.40A
)
3ESN
(X-ray
1.35A
)
3ESO
(X-ray
1.31A
)
3ESP
(X-ray
1.31A
)
3FC8
(X-ray
1.85A
)
3FCB
(X-ray
1.80A
)
3GLZ
(X-ray
1.78A
)
3GPS
(X-ray
1.78A
)
3GRB
(X-ray
1.75A
)
3GRG
(X-ray
1.90A
)
3GS0
(X-ray
1.85A
)
3GS4
(X-ray
1.78A
)
3GS7
(X-ray
1.80A
)
3HJ0
(X-ray
1.34A
)
3I9A
(X-ray
1.65A
)
3I9I
(X-ray
1.80A
)
3I9P
(X-ray
1.90A
)
3IMR
(X-ray
1.70A
)
3IMS
(X-ray
1.40A
)
3IMT
(X-ray
1.40A
)
3IMU
(X-ray
1.40A
)
3IMV
(X-ray
1.47A
)
3IMW
(X-ray
1.31A
)
3IPB
(X-ray
1.90A
)
3IPE
(X-ray
1.40A
)
3KGS
(X-ray
1.80A
)
3KGT
(X-ray
1.95A
)
3KGU
(X-ray
1.85A
)
3M1O
(X-ray
1.20A
)
3NEE
(X-ray
1.55A
)
3NEO
(X-ray
2.00A
)
3NES
(X-ray
1.75A
)
3NEX
(X-ray
1.70A
)
3NG5
(X-ray
1.70A
)
3OZK
(X-ray
1.90A
)
3OZL
(X-ray
1.90A
)
3P3R
(X-ray
1.25A
)
3P3S
(X-ray
1.60A
)
3P3T
(X-ray
1.45A
)
3P3U
(X-ray
1.50A
)
3SSG
(X-ray
2.00A
)
3TCT
(X-ray
1.30A
)
3TFB
(X-ray
2.03A
)
3U2I
(X-ray
1.70A
)
3U2J
(Neutron
2.00A
)
3W3B
(X-ray
1.90A
)
4ABQ
(X-ray
1.70A
)
4ABU
(X-ray
1.86A
)
4ABV
(X-ray
1.80A
)
4ABW
(X-ray
1.70A
)
4AC2
(X-ray
1.81A
)
4AC4
(X-ray
1.80A
)
4ACT
(X-ray
1.80A
)
4ANK
(X-ray
1.70A
)
4D7B
(X-ray
1.15A
)
4DER
(X-ray
1.90A
)
4DES
(X-ray
1.75A
)
4DET
(X-ray
2.05A
)
4DEU
(X-ray
1.60A
)
4DEW
(X-ray
1.90A
)
4FI6
(X-ray
1.46A
)
4FI7
(X-ray
1.40A
)
4FI8
(X-ray
1.22A
)
4HIQ
(X-ray
1.18A
)
4HIS
(X-ray
1.20A
)
4HJS
(X-ray
1.22A
)
4HJT
(X-ray
1.45A
)
4HJU
(X-ray
1.35A
)
4I85
(X-ray
1.67A
)
4I87
(X-ray
1.69A
)
4I89
(X-ray
1.69A
)
4IIZ
(X-ray
2.10A
)
4IK6
(X-ray
2.00A
)
4IK7
(X-ray
2.10A
)
4IKI
(X-ray
2.00A
)
4IKJ
(X-ray
2.10A
)
4IKK
(X-ray
1.90A
)
4IKL
(X-ray
1.90A
)
4KY2
(X-ray
1.13A
)
4L1S
(X-ray
1.50A
)
4L1T
(X-ray
1.16A
)
4MAS
(X-ray
1.22A
)
4MRB
(X-ray
1.27A
)
4MRC
(X-ray
1.54A
)
4N85
(X-ray
1.60A
)
4N86
(X-ray
2.00A
)
4N87
(X-ray
1.79A
)
4PM1
(X-ray
1.23A
)
4PME
(X-ray
1.26A
)
4PMF
(X-ray
1.35A
)
4PVL
(X-ray
1.85A
)
4PVM
(Other
2.00A
)
4PVN
(Other
2.30A
)
4PWE
(X-ray
1.40A
)
4PWF
(X-ray
1.60A
)
4PWG
(X-ray
1.80A
)
4PWH
(X-ray
1.80A
)
4PWI
(X-ray
1.49A
)
4PWJ
(X-ray
1.55A
)
4PWK
(X-ray
1.59A
)
4QRF
(X-ray
1.80A
)
4QXV
(X-ray
1.12A
)
4QYA
(X-ray
1.70A
)
4TKW
(X-ray
1.80A
)
4TL4
(X-ray
1.75A
)
4TL5
(X-ray
1.44A
)
4TLK
(X-ray
1.44A
)
4TLS
(X-ray
1.35A
)
4TLT
(X-ray
1.70A
)
4TLU
(X-ray
1.75A
)
4TM9
(X-ray
1.70A
)
4TNE
(X-ray
1.55A
)
4TNF
(X-ray
1.60A
)
4TNG
(X-ray
1.60A
)
4TQ8
(X-ray
1.52A
)
4TQH
(X-ray
1.51A
)
4TQI
(X-ray
1.25A
)
4TQP
(X-ray
1.58A
)
4WNJ
(X-ray
1.40A
)
4WNS
(X-ray
1.40A
)
4WO0
(X-ray
1.34A
)
4Y9B
(X-ray
1.40A
)
4Y9C
(X-ray
1.49A
)
4Y9E
(X-ray
1.49A
)
4Y9F
(X-ray
1.50A
)
4Y9G
(X-ray
1.89A
)
4YDM
(X-ray
1.25A
)
4YDN
(X-ray
1.35A
)
5A6I
(X-ray
1.86A
)
5AKS
(X-ray
1.25A
)
5AKT
(X-ray
1.35A
)
5AKV
(X-ray
1.52A
)
5AL0
(X-ray
1.39A
)
5AL8
(X-ray
1.50A
)
5AYT
(X-ray
1.40A
)
5BOJ
(X-ray
1.75A
)
5CLX
(X-ray
1.28A
)
5CLY
(X-ray
1.23A
)
5CLZ
(X-ray
1.22A
)
5CM1
(X-ray
1.22A
)
5CN3
(X-ray
1.30A
)
5CNH
(X-ray
1.42A
)
5CR1
(X-ray
1.54A
)
5DEJ
(X-ray
1.37A
)
5DWP
(X-ray
1.20A
)
5E23
(X-ray
1.41A
)
5E4A
(X-ray
1.33A
)
5E4O
(X-ray
1.50A
)
5EN3
(X-ray
1.25A
)
5EZP
(X-ray
2.50A
)
5FO2
(X-ray
1.45A
)
5FW6
(X-ray
1.30A
)
5FW7
(X-ray
1.20A
)
5FW8
(X-ray
1.60A
)
5H0V
(X-ray
1.58A
)
5H0W
(X-ray
1.90A
)
5H0X
(X-ray
1.57A
)
5H0Y
(X-ray
1.80A
)
5H0Z
(X-ray
1.74A
)
5HJG
(X-ray
1.40A
)
5IHH
(X-ray
1.35A
)
5JID
(X-ray
1.20A
)
5JIM
(X-ray
1.26A
)
5JIQ
(X-ray
1.45A
)
5K1J
(X-ray
1.69A
)
5K1N
(X-ray
1.81A
)
5L4F
(X-ray
1.48A
)
5L4I
(X-ray
1.45A
)
5L4J
(X-ray
1.62A
)
5L4M
(X-ray
1.58A
)
5LLL
(X-ray
1.42A
)
5LLV
(X-ray
1.70A
)
5N5Q
(X-ray
2.53A
)
5N62
(X-ray
1.80A
)
5N7C
(X-ray
2.45A
)
5NFE
(Other
1.85A
)
5NFW
(Other
1.80A
)
5OQ0
(X-ray
1.94A
)
5TTR
(X-ray
2.70A
)
5TZL
(X-ray
1.40A
)
5U48
(X-ray
1.50A
)
5U49
(X-ray
2.22A
)
5U4A
(X-ray
1.90A
)
5U4B
(X-ray
1.45A
)
5U4C
(X-ray
1.70A
)
5U4D
(X-ray
1.55A
)
5U4E
(X-ray
1.45A
)
5U4F
(X-ray
1.50A
)
5U4G
(X-ray
1.80A
)
6D0W
(X-ray
1.70A
)
6E6Z
(X-ray
1.75A
)
6E70
(X-ray
1.99A
)
6E71
(X-ray
1.50A
)
6E72
(X-ray
1.45A
)
6E73
(X-ray
1.80A
)
6E74
(X-ray
1.60A
)
6E75
(X-ray
1.50A
)
6E76
(X-ray
1.60A
)
6E77
(X-ray
1.60A
)
6E78
(X-ray
1.50A
)
6EOY
(X-ray
1.38A
)
6EP1
(X-ray
1.30A
)
6FFT
(Other
2.00A
)
6FWD
(X-ray
1.58A
)
6FXU
(X-ray
1.36A
)
6FZL
(X-ray
1.45A
)
6GR7
(X-ray
1.40A
)
6GRP
(X-ray
1.60A
)
6IMX
(X-ray
1.60A
)
6IMY
(X-ray
1.50A
)
6KGB
(X-ray
1.30A
)
6R66
(X-ray
1.30A
)
6R67
(X-ray
1.30A
)
6R68
(X-ray
1.45A
)
6R6I
(X-ray
1.47A
)
6SDZ
(EM
2.97A
)
6SUG
(X-ray
1.21A
)
6SUH
(X-ray
1.26A
)
6TI9
(X-ray
1.45A
)
6TJN
(X-ray
1.70A
)
6TXV
(X-ray
1.60A
)
6TXW
(X-ray
1.15A
)
6U0Q
(X-ray
1.75A
)
6XTK
(X-ray
1.70A
)
7ACU
(X-ray
1.54A
)
7DT3
(X-ray
1.20A
)
7DT5
(X-ray
1.25A
)
7DT6
(X-ray
1.30A
)
7DT8
(X-ray
1.25A
)
7EJQ
(X-ray
1.15A
)
7EJR
(X-ray
1.45A
)
7ERH
(X-ray
1.55A
)
7ERI
(X-ray
1.81A
)
7ERJ
(X-ray
1.89A
)
7ERK
(X-ray
1.70A
)
7OB4
(EM
3.22A
)
7Z60
(X-ray
1.40A
)
DBSNP
rs1800458
rs121918083
rs121918094
rs121918098
rs121918093
rs11541790
rs79977247
rs79977247
rs28933979
rs28933979
rs121918068
rs121918068
rs121918077
rs11541796
rs11541796
rs104894665
rs730881169
rs121918078
rs121918090
rs387906523
rs121918081
rs121918080
rs386134269
rs121918097
rs121918079
rs121918069
rs121918069
rs730881163
rs121918070
rs121918086
rs121918091
rs121918085
rs121918100
rs267607160
rs121918084
rs730881164
rs121918071
rs958191819
rs121918072
rs121918082
rs121918074
rs121918087
rs267607161
rs755337715
rs745834030
rs121918095
rs1456101911
rs121918089
rs267607159
rs121918073
rs121918075
rs121918088
rs730881167
rs28933981
rs876658108
rs76992529
rs144965179
Subcellular location [CC]
Secreted. Cytoplasm.
Mouse PG classification
LPG
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