| Gene Information | |
|---|---|
| Gene Name | TOPORS |
| Organism | Homo sapiens (Human) |
| Gene Length | 1045 |
| Protein Names | E3 ubiquitin-protein ligase Topors (EC 2.3.2.27) (RING-type E3 ubiquitin transferase Topors) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000197579 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NS56 |
| Gene Card | TOPORS |
| Uniprot ID | Q9NS56 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.579024909) |
| Ortholog in Animals | Alpaca_ TOPORS ( ortholog_one2one ) Dog_ TOPORS ( ortholog_one2one ) GuineaPig_ TOPORS ( ortholog_one2one ) Macaque_ TOPORS ( ortholog_one2one ) Mouse_ Topors ( ortholog_one2one ) Pig_ TOPORS ( ortholog_one2one ) Rat_ Topors ( ortholog_one2one ) Rabbit_ TOPORS ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at highest levels in testis and at lower levels in adrenal gland, bone marrow, brain, colon, heart, kidney, liver, muscle, ovary, pancreas, placenta, prostate, skeletal muscle, skin, small intestine, spleen, stomach, testis, thymus, thyroid and uterus. Expressed in the alveolar epithelium of the lung. Expression is commonly decreased in colon adenocarcinomas and lung cancers. {ECO:0000269|PubMed:10415337, ECO:0000269|PubMed:11278651, ECO:0000269|PubMed:15107820}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs17855104 rs17855103 rs17857515 rs36034138 |
| Subcellular location [CC] | Nucleus. Nucleus, PML body. Note=Localizes to discrete nuclear foci which partly overlap with PML nuclear bodies. Targeted to PML nuclear bodies upon DNA damage. |
| Mouse PG classification | NA |
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