| Gene Information | |
|---|---|
| Gene Name | TTP |
| Organism | Homo sapiens (Human) |
| Gene Length | 963 |
| Protein Names | SH3 domain-binding protein 4 (EH-binding protein 10) (Transferrin receptor-trafficking protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9P0V3 |
| Gene Card | SH3BP4 |
| Uniprot ID | Q9P0V3 |
| Pfam | PF00018; PF07653; PF00791 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues tested with higher expression in pancreas. Expressed by retinal pigment epithelial cells (at protein level). {ECO:0000269|PubMed:10644451, ECO:0000269|PubMed:15616480}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs3731644 rs3731646 |
| Subcellular location [CC] | Membrane, clathrin-coated pit. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus {ECO:0000305}. Note=Specifically associated with transferrin receptor-containing clathrin-coated pits and clathrin-coated vesicles. May also localize to the nucleus. |
| Mouse PG classification | NA |
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