Gene Information

Gene Information
Gene Name	TTN
Organism	Homo sapiens (Human)
Gene Length	34350
Protein Names	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14)
Target Name	NA
Target Type	NA
Gene Age	680 ( ENSG00000155657 )
Evolutionary Stage	Eumetazoa
AlphaFoldDB	NA
Gene Card	TTN
Uniprot ID	Q8WZ42
Pfam	PF00041; PF07679; PF00069; PF02818; PF18362; PF09042
In ASD	no
Allosteric Prediction	yes (0.397469708)
Ortholog in Animals	Alpaca_ TTN ( ortholog_one2one ) Macaque_ TTN ( ortholog_one2one ) Mouse_ Ttn ( ortholog_one2one ) Rat_ Ttn ( ortholog_one2one )
Ohnologs	NA
Paralogs	NA
Tissue	heart, skeletal.muscle, artery, penis, tongue
Tissue Specificity	Isoforms 3, 7 and 8 are expressed in cardiac muscle. Isoform 4 is expressed in vertebrate skeletal muscle. Isoform 6 is expressed in skeletal muscle (at protein level). {ECO:0000269\|PubMed:11717165, ECO:0000269\|PubMed:7819249}.
Pharmacological Animal Models	NA
Gene Ontology (biological process)
Gene Ontology (cellular component)
Gene Ontology (molecular function)
PDB	1BPV (NMR - ) 1G1C (X-ray 2.10A ) 1NCT (NMR - ) 1NCU (NMR - ) 1TIT (NMR - ) 1TIU (NMR - ) 1TKI (X-ray 2.00A ) 1TNM (NMR - ) 1TNN (NMR - ) 1WAA (X-ray 1.80A ) 1YA5 (X-ray 2.44A ) 2A38 (X-ray 2.00A ) 2BK8 (X-ray 1.69A ) 2F8V (X-ray 2.75A ) 2ILL (X-ray 2.20A ) 2J8H (X-ray 1.99A ) 2J8O (X-ray 2.49A ) 2NZI (X-ray 2.90A ) 2RQ8 (NMR - ) 2WP3 (X-ray 1.48A ) 2WWK (X-ray 1.70A ) 2WWM (X-ray 2.30A ) 2Y9R (X-ray 1.90A ) 3B43 (X-ray 3.30A ) 3KNB (X-ray 1.40A ) 3LCY (X-ray 2.50A ) 3LPW (X-ray 1.65A ) 3PUC (X-ray 0.96A ) 3Q5O (X-ray 2.05A ) 3QP3 (X-ray 2.00A ) 4C4K (X-ray 1.95A ) 4JNW (X-ray 2.06A ) 4O00 (X-ray 1.85A ) 4QEG (X-ray 2.00A ) 4UOW (X-ray 3.30A ) 5BS0 (X-ray 2.40A ) 5JDD (X-ray 1.53A ) 5JDE (X-ray 1.90A ) 5JDJ (X-ray 1.74A ) 5JOE (X-ray 2.00A ) 6DL4 (NMR - ) 6FWX (X-ray 3.00A ) 6H4L (X-ray 1.60A ) 6HCI (X-ray 2.12A ) 6I0Y (EM 3.20A ) 6SDB (X-ray 2.80A ) 6YGN (X-ray 2.40A ) 7AHS (X-ray 2.05A ) 7NIP (NMR - )
DBSNP	rs139517732 rs35683768 rs564777385 rs138060032 rs16866538 rs56128843 rs72647851 rs28933405 rs267607157 rs149061352 rs35813871 rs56046320 rs267607155 rs55914517 rs72647870 rs10497520 rs150667217 rs1552280 rs1552280 rs36021856 rs267599092 rs539470256 rs36062108 rs16866531 rs72647875 rs72647876 rs72647877 rs12476289 rs56270960 rs375029799 rs370004591 rs75686037 rs150725992 rs144135510 rs56404770 rs56285559 rs4894048 rs571572592 rs56142888 rs576644663 rs33917087 rs2306636 rs56373393 rs200875815 rs11900987 rs4893853 rs33997263 rs397517792 rs55634230 rs2291311 rs34819099 rs2291310 rs2627037 rs55853696 rs757223770 rs34070843 rs34618570 rs56244420 rs200431386 rs2562829 rs56030296 rs1883085 rs55857742 rs55906845 rs281864908 rs16866412 rs4893852 rs55723264 rs2288563 rs34706299 rs199684560 rs778634417 rs6723526 rs200914097 rs1458591077 rs373298007 rs571522834 rs74580375 rs144668626 rs114331773 rs184078045 rs17354992 rs72677225 rs72677232 rs72677233 rs146181477 rs200944827 rs55663050 rs36043230 rs16866412 rs751398376 rs201825412 rs200650668 rs370390570 rs755155531 rs554368924 rs780672348 rs72646808 rs2303832 rs72646809 rs373526624 rs55734111 rs3813243 rs55809450 rs72646823 rs1001238 rs56025724 rs2288569 rs374713701 rs769852851 rs200732032 rs16866406 rs141973925 rs1336054298 rs1204056923 rs1470758075 rs199895260 rs1383995916 rs72646850 rs773075736 rs202240487 rs2042996 rs181717727 rs150661999 rs141965360 rs72646861 rs13021201 rs56378177 rs55948748 rs200217934 rs9808036 rs72646869 rs2303838 rs72646873 rs750847940 rs534340303 rs55980498 rs56141309 rs55853138 rs55713867 rs55801134 rs56071233 rs55903402 rs55677134 rs55885640 rs55837610 rs56019808 rs10164753 rs56399205 rs55992239 rs56201325 rs55991022 rs764005465 rs369098292 rs55762754 rs55713856 rs744426 rs3813243 rs55984930 rs3813245 rs56372592 rs56391938 rs4894028 rs3813246 rs56340968 rs56018860 rs56341835 rs12463674 rs3731745 rs56044609 rs56307213 rs3731746 rs55850344 rs56365600 rs56137800 rs55933739 rs375422359 rs56264840 rs55634791 rs56309296 rs3829746 rs56057221 rs56330345 rs1186947794 rs191482653 rs55898359 rs55940667 rs9808377 rs139506970 rs77853750 rs72648238 rs149567378 rs114026724 rs148617456 rs535151633 rs376628842 rs373049260 rs747122 rs16866391 rs750303653 rs1310673663 rs72648256 rs72648257 rs142525903 rs191484894 rs62621206 rs62621236 rs56027402 rs397517769 rs56009327 rs55915651 rs55660660 rs56066673 rs56233675 rs3731749 rs55676195 rs55704830 rs72648270 rs72648272 rs72648273 rs149001703 rs55653324 rs4894028 rs56061641 rs55742743 rs55675869 rs55880786 rs2278196 rs56273463 rs34924609 rs55886356 rs55669553 rs756924372 rs56347248 rs56173891 rs3731752 rs148525155 rs55945684 rs3829747 rs199642423 rs55866005 rs1003158162 rs56001826 rs56308529 rs55865284 rs56365812 rs56324595 rs16866380 rs55725279 rs55880440 rs55842557 rs16866378 rs281864928 rs267607156
Subcellular location [CC]	Cytoplasm {ECO:0000305\|PubMed:16410549}. Nucleus {ECO:0000269\|PubMed:16410549}.
Mouse PG classification	NA
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