| Gene Information | |
|---|---|
| Gene Name | DENND2D |
| Organism | Homo sapiens (Human) |
| Gene Length | 471 |
| Protein Names | DENN domain-containing protein 2D |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000162777 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9H6A0 |
| Gene Card | DENND2D |
| Uniprot ID | Q9H6A0 |
| Pfam | PF03455; PF02141; PF03456 |
| In ASD | no |
| Allosteric Prediction | no (-0.368125699) |
| Ortholog in Animals | Alpaca_ DENND2D ( ortholog_one2one ) Dog_ DENND2D ( ortholog_one2one ) GuineaPig_ DENND2D ( ortholog_one2one ) Macaque_ DENND2D ( ortholog_one2one ) Mouse_ Dennd2d ( ortholog_one2one ) Pig_ DENND2D ( ortholog_one2one ) Rat_ Dennd2d ( ortholog_one2one ) Rabbit_ DENND2D ( ortholog_one2one ) |
| Ohnologs | DENND2A, DENND2B |
| Paralogs | DENND2B, DENND2C, DENND2A |
| Tissue | NA |
| Tissue Specificity | In bronchial mucosa, mainly expressed in ciliated and basal epithelial cells and weakly in alveolar cells (at protein level). Tends to be down-regulated in lung cancers, immortalized bronchial epithelial cell lines and precancerous lesions. {ECO:0000269|PubMed:23182661}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs35742969 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:23182661}. |
| Mouse PG classification | NA |
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