| Gene Information | |
|---|---|
| Gene Name | TTLL5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1281 |
| Protein Names | Tubulin polyglutamylase TTLL5 (EC 6.3.2.-) (SRC1 and TIF2-associated modulatory protein) (STAMP protein) (Tubulin--tyrosine ligase-like protein 5) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000119685 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q6EMB2 |
| Gene Card | TTLL5 |
| Uniprot ID | Q6EMB2 |
| Pfam | PF03133 |
| In ASD | no |
| Allosteric Prediction | no (-1.278233792) |
| Ortholog in Animals | Alpaca_ TTLL5 ( ortholog_one2one ) Dog_ TTLL5 ( ortholog_one2one ) Macaque_ TTLL5 ( ortholog_one2one ) Pig_ TTLL5 ( ortholog_one2one ) Rabbit_ TTLL5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | testis |
| Tissue Specificity | Expressed in the retina, found in the rod and cone photoreceptors (at protein level). Widely expressed with highest levels in heart and skeletal muscle and low levels in other tissues. {ECO:0000269|PubMed:17116691, ECO:0000269|PubMed:24791901}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2303345 rs17856074 rs199882533 rs11848004 rs10130991 rs11844617 rs1133834 |
| Subcellular location [CC] | Cell projection, cilium {ECO:0000269|PubMed:24791901}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q8CHB8}. Nucleus {ECO:0000269|PubMed:17116691}. Cytoplasm {ECO:0000269|PubMed:17116691}. Note=Localized to the base of the connecting cilium between the basal body and the adjacent daughter centriole of the cilium. In osteosarcoma cells, found in both cytoplasm and nucleus in the absence of steroid but located exclusively in the nucleus in the presence of steroid. {ECO:0000250|UniProtKB:Q8CHB8, ECO:0000269|PubMed:24791901}. |
| Mouse PG classification | NA |
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