| Gene Information | |
|---|---|
| Gene Name | ZIC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 447 |
| Protein Names | Zinc finger protein ZIC 1 (Zinc finger protein 201) (Zinc finger protein of the cerebellum 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000152977 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q15915 |
| Gene Card | ZIC1 |
| Uniprot ID | Q15915 |
| Pfam | PF00096; PF18366 |
| In ASD | no |
| Allosteric Prediction | no (-0.946110239) |
| Ortholog in Animals | Alpaca_ ZIC1 ( ortholog_one2one ) Dog_ ZIC1 ( ortholog_one2one ) Macaque_ ZIC1 ( ortholog_one2one ) Mouse_ Zic1 ( ortholog_one2one ) Pig_ ZIC1 ( ortholog_one2one ) Rat_ Zic1 ( ortholog_one2one ) |
| Ohnologs | ZIC2, ZIC5, ZIC3 |
| Paralogs | AEBP2, GLIS3, GLI2, ZXDC, GLIS2, GLIS1, ZXDA, ZXDB, ZIC4, ZIC5, ZIC3, ZIC2, GLI1, GLI3 |
| Tissue | brain, cerebellar.hemisphere, cerebellum |
| Tissue Specificity | CNS. A high level expression is seen in the cerebellum. Detected in the nuclei of the cerebellar granule cell lineage from the progenitor cells of the external germinal layer to the postmigrated cells of the internal granular layer. Detected in medulloblastoma (26/29 cases), but not present in all other tumors examined. {ECO:0000269|PubMed:8542595}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1057517670 rs143292136 |
| Subcellular location [CC] | Nucleus. Cytoplasm {ECO:0000250}. Note=Localizes in the cytoplasm in presence of MDFIC overexpression. {ECO:0000250}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |