| Gene Information | |
|---|---|
| Gene Name | TTC4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 387 |
| Protein Names | Tetratricopeptide repeat protein 4 (TPR repeat protein 4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000243725 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O95801 |
| Gene Card | TTC4 |
| Uniprot ID | O95801 |
| Pfam | PF18972 |
| In ASD | no |
| Allosteric Prediction | no (-0.960275995) |
| Ortholog in Animals | Alpaca_ TTC4 ( ortholog_one2one ) Dog_ TTC4 ( ortholog_one2one ) GuineaPig_ TTC4 ( ortholog_one2one ) Macaque_ TTC4 ( ortholog_one2one ) Mouse_ Ttc4 ( ortholog_one2one ) Pig_ TTC4 ( ortholog_one2one ) Rat_ Ttc4 ( ortholog_one2one ) Rabbit_ TTC4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TTC1, TTC32, SUGT1, UNC45A, TOMM34, SPAG1, SGTB, UNC45B, TOMM70, DNAAF4, TTC31, ST13, TTC12, STIP1, SPATA16, SGTA, RPAP3, STUB1 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in proliferating tissue and tumor cell lines but not in normal cell lines. {ECO:0000269|PubMed:18320024}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001635(Rat);0.03125(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6HFO (X-ray 1.65A ) |
| DBSNP | rs1147990 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:18320024, ECO:0000269|PubMed:29251827}. Nucleus, nucleoplasm {ECO:0000269|PubMed:18320024}. Cytoplasm {ECO:0000269|PubMed:29251827}. Note=Predominantly nuclear in the G1 and S phases of cell cycle and is evenly distributed between the nucleus and cytoplasm in the G2 phase (By similarity). MSL1 can promote its nuclear localization (By similarity). {ECO:0000250|UniProtKB:Q8R3H9}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |