| Gene Information | |
|---|---|
| Gene Name | TTC3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2025 |
| Protein Names | E3 ubiquitin-protein ligase TTC3 (EC 2.3.2.27) (Protein DCRR1) (RING finger protein 105) (RING-type E3 ubiquitin transferase TTC3) (TPR repeat protein D) (Tetratricopeptide repeat protein 3) (TPR repeat protein 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000182670 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P53804 |
| Gene Card | TTC3 |
| Uniprot ID | P53804 |
| Pfam | PF19179; PF13639 |
| In ASD | no |
| Allosteric Prediction | yes (0.103738363) |
| Ortholog in Animals | Alpaca_ TTC3 ( ortholog_one2one ) Dog_ TTC3 ( ortholog_one2one ) Macaque_ TTC3 ( ortholog_one2one ) Mouse_ Ttc3 ( ortholog_one2one ) Pig_ TTC3 ( ortholog_one2one ) Rat_ Ttc3 ( ortholog_one2one ) Rabbit_ TTC3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Found in all tissues examined. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1053808 rs377155188 rs1053840 rs1053966 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:20059950, ECO:0000269|PubMed:30203323}. Cytoplasm {ECO:0000269|PubMed:30203323}. Golgi apparatus {ECO:0000250|UniProtKB:D3ZSP7}. Note=Nuclear localization may be dependent on the proteolytic cleavage of full length protein in the cytoplasm (PubMed:30203323). This cleavage may reveal an N-terminal nuclear localization signal, allowing N-terminal fragments to enter the nucleus (PubMed:30203323). {ECO:0000269|PubMed:30203323}. |
| Mouse PG classification | NA |
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