| Gene Information | |
|---|---|
| Gene Name | TSPOAP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1857 |
| Protein Names | Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIMS-binding protein 1) (RIM-BP1) (TSPO-associated protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000005379 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | O95153 |
| Gene Card | TSPOAP1 |
| Uniprot ID | O95153 |
| Pfam | PF07653; PF14604 |
| In ASD | no |
| Allosteric Prediction | yes (0.174900397) |
| Ortholog in Animals | Alpaca_ TSPOAP1 ( ortholog_one2one ) Dog_ TSPOAP1 ( ortholog_one2one ) GuineaPig_ TSPOAP1 ( ortholog_one2one ) Macaque_ TSPOAP1 ( ortholog_one2one ) Mouse_ Tspoap1 ( ortholog_one2one ) Pig_ TSPOAP1 ( ortholog_one2one ) Rat_ Tspoap1 ( ortholog_one2one ) Rabbit_ TSPOAP1 ( ortholog_one2one ) |
| Ohnologs | RIMBP2 |
| Paralogs | RIMBP2, RIMBP3B, RIMBP3C, RIMBP3 |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in brain, pituitary gland and thymus in adults. In adult brain, highest expression found in temporal lobe and the putamen, followed by amygdala, caudate nucleus, cerebral cortex, occipital and frontal lobe. A high expression level is also observed in fetal tissues like brain, heart, kidney and thymus. {ECO:0000269|PubMed:9915832}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2072145 rs2072147 rs373894175 rs9913145 rs9905604 rs3744099 rs2680704 rs3744101 rs11079346 rs2301868 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:9915832}. Mitochondrion {ECO:0000269|PubMed:9915832}. Note=Preferentially expressed in the mitochondria in the presence of TSPO. |
| Mouse PG classification | NA |
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