| Gene Information | |
|---|---|
| Gene Name | NPFFR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 522 |
| Protein Names | Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (G-protein coupled receptor HLWAR77) (Neuropeptide G-protein coupled receptor) |
| Target Name | neuropeptide ff receptor 2 |
| Target Type | Literature-reported target |
| Gene Age | 544 ( ENSG00000056291 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9Y5X5 |
| Gene Card | NPFFR2 |
| Uniprot ID | Q9Y5X5 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (1.215246977) |
| Ortholog in Animals | Alpaca_ NPFFR2 ( ortholog_one2one ) Dog_ NPFFR2 ( ortholog_one2one ) Macaque_ NPFFR2 ( ortholog_one2one ) Mouse_ Npffr2 ( ortholog_one2one ) Pig_ NPFFR2 ( ortholog_one2one ) Rat_ Npffr2 ( ortholog_one2one ) Rabbit_ NPFFR2 ( ortholog_one2one ) |
| Ohnologs | NPFFR1, NPY2R, HCRTR1 |
| Paralogs | NPFFR1, HCRTR2, HCRTR1, CCKBR, CCKAR, OXTR, AVPR2, AVPR1B, AVPR1A, GNRHR, GALR3, GPR22, GPR150, FFAR4, GALR1, QRFPR |
| Tissue | placenta |
| Tissue Specificity | Isoform 1 is abundant in placenta. Relatively highly expressed in thymus, testis, and small intestine. Expressed at low levels in several tissues including spleen, prostate, brain, heart, ovary, colon, kidney, lung, liver and pancreas and not expressed in skeletal muscle and leukocytes. Isoform 2 expression is highest in placenta (but at relatively low level compared to isoform 1). Very low level of expression in numerous tissues including adipose tissue and many brain regions. Isoform 3 is expressed in brain and heart and, at lower levels, in kidney, liver, lung and pancreas. {ECO:0000269|PubMed:10079187}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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