| Gene Information | |
|---|---|
| Gene Name | GPR75 |
| Organism | Homo sapiens (Human) |
| Gene Length | 540 |
| Protein Names | Probable G-protein coupled receptor 75 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000119737 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | O95800 |
| Gene Card | GPR75 |
| Uniprot ID | O95800 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | no (-0.999585956) |
| Ortholog in Animals | Dog_ GPR75 ( ortholog_one2one ) GuineaPig_ GPR75 ( ortholog_one2one ) Macaque_ GPR75 ( ortholog_one2one ) Mouse_ Gpr75 ( ortholog_one2one ) Pig_ GPR75 ( ortholog_one2one ) Rat_ Gpr75 ( ortholog_one2one ) Rabbit_ GPR75 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TACR2, OR9A2, NPY1R, MTNR1B, OR11H6, OR11H7, OR11H4, OR9A1P, OR9G1, NPY2R, MTNR1A, GPR50, OR11G2, MCHR2, MCHR1, GPR19, OR11A1, TACR1, TACR3, OR11H2, OR11H12, OR11H1, GPR83, PROKR2, PROKR1, GPR88, PRLHR, OR51F1, OR10X1, NPY5R, OR9A4, NPY4R2, NPY4R |
| Tissue | NA |
| Tissue Specificity | Expressed at high levels in brain and spinal cord and at detectable levels in retinal pigment epithelium. In situ hybridization of adult eye sections localized transcripts only to the perivascular cells, surrounding retinal arterioles, in the ganglion cell/nerve fiber layer. Also expressed by islet cells (at protein level). {ECO:0000269|PubMed:10381362, ECO:0000269|PubMed:11466257, ECO:0000269|PubMed:23979485}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs72799238 rs763005023 rs34000641 rs35349235 rs3731969 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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