| Gene Information | |
|---|---|
| Gene Name | TSP |
| Organism | Homo sapiens (Human) |
| Gene Length | 1170 |
| Protein Names | Thrombospondin-1 (Glycoprotein G) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P07996 |
| Gene Card | THBS1 |
| Uniprot ID | P07996 |
| Pfam | PF00090; PF02412; PF05735; PF00093 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1LSL (X-ray 1.90A ) 1UX6 (X-ray 1.90A ) 1Z78 (X-ray 1.80A ) 1ZA4 (X-ray 1.90A ) 2ERF (X-ray 1.45A ) 2ES3 (X-ray 1.85A ) 2OUH (X-ray 2.40A ) 2OUJ (X-ray 1.90A ) 3R6B (X-ray 2.40A ) 5FOE (X-ray 1.98A ) 7YYK (X-ray 2.60A ) |
| DBSNP | rs41515347 rs2292305 rs2228262 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:6777381}. Cell surface {ECO:0000269|PubMed:6777381}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:6341993}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P35441}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:P35441}. Note=Secreted by thrombin-activated platelets and binds to the cell surface in the presence of extracellular Ca(2+) (PubMed:6777381). Incorporated into the extracellular matrix of fibroblasts (PubMed:6341993). Also detected in the endoplasmic reticulum and sarcoplasmic reticulum where it plays a role in the ER stress response (By similarity). {ECO:0000250|UniProtKB:P35441, ECO:0000269|PubMed:6341993, ECO:0000269|PubMed:6777381}. |
| Mouse PG classification | NA |
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