| Gene Information | |
|---|---|
| Gene Name | TSHZ3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1081 |
| Protein Names | Teashirt homolog 3 (Zinc finger protein 537) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000121297 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q63HK5 |
| Gene Card | TSHZ3 |
| Uniprot ID | Q63HK5 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.389187312) |
| Ortholog in Animals | Alpaca_ TSHZ3 ( ortholog_one2one ) Dog_ TSHZ3 ( ortholog_one2one ) GuineaPig_ TSHZ3 ( ortholog_one2one ) Macaque_ TSHZ3 ( ortholog_one2one ) Mouse_ Tshz3 ( ortholog_one2one ) Pig_ TSHZ3 ( ortholog_one2one ) Rat_ Tshz3 ( ortholog_one2one ) Rabbit_ TSHZ3 ( ortholog_one2one ) |
| Ohnologs | TSHZ2 |
| Paralogs | TSHZ1, TSHZ2 |
| Tissue | NA |
| Tissue Specificity | Expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease (PubMed:18776146, PubMed:19343227). Expressed in the fetal neocortex (PubMed:27668656). {ECO:0000269|PubMed:18776146, ECO:0000269|PubMed:19343227, ECO:0000269|PubMed:27668656}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2DMI (NMR - ) |
| DBSNP | rs143453460 rs4805664 |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:19343227}. Cell projection, growth cone {ECO:0000250}. Note=Colocalizes with APBB1 in axonal growth cone (By similarity). Colocalizes with APBB1 in the nucleus. {ECO:0000250}. |
| Mouse PG classification | NA |
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