| Gene Information | |
|---|---|
| Gene Name | TSG101 |
| Organism | Homo sapiens (Human) |
| Gene Length | 390 |
| Protein Names | Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101) |
| Target Name | tumor susceptibility gene protein 101 |
| Target Type | Clinical trial target |
| Gene Age | 1488 ( ENSG00000074319 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q99816 |
| Gene Card | TSG101 |
| Uniprot ID | Q99816 |
| Pfam | PF05743; PF09454 |
| In ASD | no |
| Allosteric Prediction | no (-0.097611062) |
| Ortholog in Animals | Alpaca_ TSG101 ( ortholog_one2one ) Dog_ TSG101 ( ortholog_one2one ) GuineaPig_ TSG101 ( ortholog_one2one ) Macaque_ TSG101 ( ortholog_one2one ) Mouse_ Tsg101 ( ortholog_one2one ) Rat_ Tsg101 ( ortholog_one2one ) Rabbit_ TSG101 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | UEVLD |
| Tissue | NA |
| Tissue Specificity | Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002138(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1KPP (NMR - ) 1KPQ (NMR - ) 1M4P (NMR - ) 1M4Q (NMR - ) 1S1Q (X-ray 2.00A ) 2F0R (X-ray 2.26A ) 3IV1 (X-ray 2.50A ) 3OBQ (X-ray 1.40A ) 3OBS (X-ray 1.50A ) 3OBU (X-ray 1.60A ) 3OBX (X-ray 1.60A ) 3P9G (X-ray 1.80A ) 3P9H (X-ray 1.80A ) 4EJE (X-ray 2.20A ) 4YC1 (X-ray 2.00A ) 4ZNY (X-ray 2.40A ) 5VKG (NMR - ) 6UD0 (NMR - ) 6VME (X-ray 2.19A ) 7NLC (X-ray 1.40A ) 7ZLX (X-ray 2.25A ) |
| DBSNP | rs34385327 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17853893}. Early endosome membrane {ECO:0000269|PubMed:23166352}; Peripheral membrane protein {ECO:0000305|PubMed:23166352}; Cytoplasmic side {ECO:0000305|PubMed:23166352}. Late endosome membrane {ECO:0000269|PubMed:11916981, ECO:0000269|PubMed:17229889}; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17853893}. Midbody, Midbody ring {ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893}. Nucleus {ECO:0000269|PubMed:17229889}. Note=Mainly cytoplasmic. Membrane-associated when active and soluble when inactive. Nuclear localization is cell cycle-dependent. Interaction with CEP55 is required for localization to the midbody during cytokinesis. {ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893}. |
| Mouse PG classification | LPG |
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