Gene Information
Gene NameSLC16A2
OrganismHomo sapiens (Human)
Gene Length539
Protein NamesMonocarboxylate transporter 8 (MCT 8) (Monocarboxylate transporter 7) (MCT 7) (Solute carrier family 16 member 2) (X-linked PEST-containing transporter)
Target Namemonocarboxylate transporter 8
Target TypeNA
Gene Age950 ( ENSG00000147100 )
Evolutionary StageEuk+Bac
AlphaFoldDBP36021
Gene CardSLC16A2
Uniprot IDP36021
PfamPF07690
In ASDno
Allosteric Predictionno (-0.06154348)
Ortholog in AnimalsAlpaca_ SLC16A2 ( ortholog_one2one )
Dog_ SLC16A2 ( ortholog_one2one )
GuineaPig_ SLC16A2 ( ortholog_one2one )
Macaque_ SLC16A2 ( ortholog_one2one )
Mouse_ Slc16a2 ( ortholog_one2one )
Pig_ SLC16A2 ( ortholog_one2one )
Rat_ Slc16a2 ( ortholog_one2one )
Rabbit_ SLC16A2 ( ortholog_one2one )
OhnologsSLC16A8, SLC16A10, SLC16A1
ParalogsSLC16A11, SLC16A10, SLC16A5, SLC16A12, SLC16A7, SLC16A14, SLC16A8, SLC16A4, SLC16A6, SLC16A1, SLC16A9, SLC16A3, SLC16A13
TissueNA
Tissue SpecificityHighly expressed in liver and heart (PubMed:7981683). In adult brain tissue expression is largely confined to endothelial cells of the blood-brain barrier (at protein level) (PubMed:32143555, PubMed:18687783). {ECO:0000269|PubMed:18687783, ECO:0000269|PubMed:32143555, ECO:0000269|PubMed:7981683}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs113994162  rs1602140936  rs373279555  rs104894936  rs727504155  rs398124232  rs12849411  rs104894939  rs587784384  rs122455132  rs113994164  rs104894931  rs794727799  rs104894938 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:20628049, ECO:0000269|PubMed:23550058, ECO:0000269|PubMed:25527620, ECO:0000269|PubMed:26426690};
Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:18687783};
Multi-pass membrane protein {ECO:0000255}.
Mouse PG classificationLPG
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