| Gene Information | |
|---|---|
| Gene Name | TRPV4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 871 |
| Protein Names | Transient receptor potential cation channel subfamily V member 4 (TrpV4) (Osm-9-like TRP channel 4) (OTRPC4) (Transient receptor potential protein 12) (TRP12) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) |
| Target Name | transient receptor potential cation channel v4 |
| Target Type | Clinical trial target |
| Gene Age | 950 ( ENSG00000111199 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9HBA0 |
| Gene Card | TRPV4 |
| Uniprot ID | Q9HBA0 |
| Pfam | PF00023; PF00520 |
| In ASD | no |
| Allosteric Prediction | yes (1.356081689) |
| Ortholog in Animals | Alpaca_ TRPV4 ( ortholog_one2one ) Dog_ TRPV4 ( ortholog_one2one ) GuineaPig_ TRPV4 ( ortholog_one2one ) Macaque_ TRPV4 ( ortholog_one2one ) Mouse_ Trpv4 ( ortholog_one2one ) Pig_ TRPV4 ( ortholog_one2one ) Rat_ Trpv4 ( ortholog_one2one ) Rabbit_ TRPV4 ( ortholog_one2one ) |
| Ohnologs | TRPV3, TRPV2, TRPV1, TRPV5, TRPV6 |
| Paralogs | TRPV3, TRPV2, TRPV5, TRPV6, TRPV1 |
| Tissue | NA |
| Tissue Specificity | Found in the synoviocytes from patients with (RA) and without (CTR) rheumatoid arthritis (at protein level). {ECO:0000269|PubMed:19759329}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4DX1 (X-ray 2.85A ) 4DX2 (X-ray 2.95A ) 7AA5 (EM 4.18A ) |
| DBSNP | rs3742030 rs397514473 rs876661124 rs387906324 rs387906903 rs515726167 rs387906904 rs267607146 rs267607144 rs387907220 rs387907219 rs515726170 rs267607148 rs515726171 rs267607143 rs267607145 rs387906905 rs121912636 rs515726172 rs121912634 rs515726152 rs387906902 rs515726158 rs77975504 rs515726159 rs515726160 rs267607150 rs515726161 rs121912632 rs515726162 rs515726163 rs121912633 rs515726164 rs116571438 rs121912635 rs515726165 rs267607149 rs267607147 rs121912637 rs121912637 rs267607147 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:29899501}. Apical cell membrane {ECO:0000269|PubMed:18695040, ECO:0000269|PubMed:18826956}; Multi-pass membrane protein {ECO:0000305}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9EPK8}. Cell projection, cilium {ECO:0000269|PubMed:18695040}. Note=Assembly of the putative homotetramer occurs primarily in the endoplasmic reticulum. {ECO:0000269|PubMed:16293632, ECO:0000269|PubMed:20037587, ECO:0000269|PubMed:20037588}.; [Isoform 1]: Cell membrane {ECO:0000269|PubMed:16293632, ECO:0000269|PubMed:21964574, ECO:0000269|PubMed:25256292}.; [Isoform 5]: Cell membrane {ECO:0000269|PubMed:16293632}.; [Isoform 2]: Endoplasmic reticulum {ECO:0000269|PubMed:16293632}.; [Isoform 4]: Endoplasmic reticulum {ECO:0000269|PubMed:16293632}.; [Isoform 6]: Endoplasmic reticulum {ECO:0000269|PubMed:16293632}. |
| Mouse PG classification | LPG |
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