| Gene Information | |
|---|---|
| Gene Name | TRPM5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1165 |
| Protein Names | Transient receptor potential cation channel subfamily M member 5 (Long transient receptor potential channel 5) (LTrpC-5) (LTrpC5) (MLSN1- and TRP-related gene 1 protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000070985 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q9NZQ8 |
| Gene Card | TRPM5 |
| Uniprot ID | Q9NZQ8 |
| Pfam | PF00520; PF18139 |
| In ASD | no |
| Allosteric Prediction | yes (0.76651401) |
| Ortholog in Animals | Alpaca_ TRPM5 ( ortholog_one2one ) Dog_ TRPM5 ( ortholog_one2one ) GuineaPig_ TRPM5 ( ortholog_one2one ) Macaque_ TRPM5 ( ortholog_one2one ) Mouse_ Trpm5 ( ortholog_one2one ) Pig_ TRPM5 ( ortholog_one2one ) Rat_ Trpm5 ( ortholog_one2one ) |
| Ohnologs | TRPM4 |
| Paralogs | TRPM3, TRPM4, TRPM1, TRPM7, TRPM8, TRPM2, TRPM6 |
| Tissue | NA |
| Tissue Specificity | Strongly expressed in fetal brain, liver and kidney, and in adult prostate, testis, ovary, colon and peripheral blood leukocytes. Also expressed in a large proportion of Wilms' tumors and rhabdomyosarcomas. In monochromosomal cell lines shows exclusive paternal expression. {ECO:0000269|PubMed:10607831}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs886277 rs3986599 rs34350821 rs34551253 rs4929982 |
| Subcellular location [CC] | Cell membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8TD43, ECO:0000255}. |
| Mouse PG classification | NA |
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