Gene Information
Gene NameTRPM3
OrganismHomo sapiens (Human)
Gene Length1732
Protein NamesTransient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC-3) (LTrpC3) (Melastatin-2) (MLSN2)
Target Namelong transient receptor potential channel 3
Target TypeLiterature-reported target
Gene Age680 ( ENSG00000083067 )
Evolutionary StageOpisthokonta
AlphaFoldDBQ9HCF6
Gene CardTRPM3
Uniprot IDQ9HCF6
PfamPF00520; PF18139; PF16519
In ASDyes
Allosteric Predictionyes (1.000420255)
Ortholog in AnimalsAlpaca_ TRPM3 ( ortholog_one2one )
Dog_ TRPM3 ( ortholog_one2one )
GuineaPig_ TRPM3 ( ortholog_one2one )
Macaque_ TRPM3 ( ortholog_one2one )
Mouse_ Trpm3 ( ortholog_one2one )
Pig_ TRPM3 ( ortholog_one2one )
Rat_ Trpm3 ( ortholog_one2one )
Rabbit_ TRPM3 ( ortholog_one2one )
OhnologsTRPM7, TRPM1
ParalogsTRPM4, TRPM5, TRPM1, TRPM7, TRPM8, TRPM2, TRPM6
Tissuekidney
Tissue SpecificityExpressed primarily in the kidney and, at lower levels, in brain, testis, ovary, pancreas and spinal cord. Expression in the brain and kidney was determined at protein level. In the kidney, expressed predominantly in the collecting tubular epithelium in the medulla, medullary rays, and periglomerular regions;
in the brain, highest levels are found in the cerebellum, choroid plexus, the locus coeruleus, the posterior thalamus and the substantia nigra. Down-regulated in renal tumors compared to normal kidney. {ECO:0000269|PubMed:12672799, ECO:0000269|PubMed:12672827}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs13440436  rs6560142  rs41287373  rs17535963 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:12672827, ECO:0000305|PubMed:21278253};
Multi-pass membrane protein {ECO:0000269|PubMed:12672827}.
Mouse PG classificationNA
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