Gene Information
Gene NameTRPM2
OrganismHomo sapiens (Human)
Gene Length1503
Protein NamesTransient receptor potential cation channel subfamily M member 2 (Estrogen-responsive element-associated gene 1 protein) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) (Transient receptor potential melastatin 2)
Target Namelong transient receptor potential channel 2
Target TypeLiterature-reported target
Gene Age950 ( ENSG00000142185 )
Evolutionary StageOpisthokonta
AlphaFoldDBO94759
Gene CardTRPM2
Uniprot IDO94759
PfamPF00520; PF18139
In ASDyes
Allosteric Predictionyes (1.276131756)
Ortholog in AnimalsAlpaca_ TRPM2 ( ortholog_one2one )
Dog_ TRPM2 ( ortholog_one2one )
GuineaPig_ TRPM2 ( ortholog_one2one )
Macaque_ TRPM2 ( ortholog_one2one )
Mouse_ Trpm2 ( ortholog_one2one )
Pig_ TRPM2 ( ortholog_one2one )
Rat_ Trpm2 ( ortholog_one2one )
OhnologsTRPM4, TRPM8
ParalogsTRPM3, TRPM4, TRPM5, TRPM1, TRPM7, TRPM8, TRPM6
TissueNA
Tissue SpecificityHighly expressed in brain and peripheral blood cells, such as neutrophils. Also detected in bone marrow, spleen, heart, liver and lung. Isoform 2 is found in neutrophil granulocytes. {ECO:0000269|PubMed:11385575, ECO:0000269|PubMed:11509734}.
Pharmacological Animal ModelsNULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6MIX  (EM  3.60A  )  6MIZ  (EM  6.10A  )  6MJ2  (EM  6.36A  )  6PUO  (EM  3.30A  )  6PUR  (EM  4.40A  )  6PUS  (EM  3.70A  )  6PUU  (EM  3.70A  )  7VQ1  (EM  3.76A  )  7VQ2  (EM  3.68A  ) 
DBSNP rs45625933  rs45544142  rs45485992  rs1556314  rs9974927  rs9978351  rs45611537  rs45519835  rs45513700  rs45589233  rs45570639  rs45613636  rs45578242 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:11385575, ECO:0000269|PubMed:11509734, ECO:0000269|PubMed:11804595, ECO:0000269|PubMed:12594222, ECO:0000269|PubMed:15561722, ECO:0000269|PubMed:16601673, ECO:0000269|PubMed:19171771, ECO:0000269|PubMed:20650899, ECO:0000269|PubMed:20660597, ECO:0000269|PubMed:22493272, ECO:0000269|PubMed:25918360, ECO:0000269|PubMed:27068538, ECO:0000269|PubMed:27383051, ECO:0000269|PubMed:30467180};
Multi-pass membrane protein {ECO:0000269|PubMed:30467180}. Perikaryon {ECO:0000250|UniProtKB:E9PTA2}. Cell projection {ECO:0000250|UniProtKB:E9PTA2}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:E9PTA2}. Lysosome {ECO:0000269|PubMed:27068538}. Note=Detected at the cell membrane and in intracellular vesicles in cortical neurons. Detected on neuronal cell bodies and neurites (By similarity). Detected on the cell membrane in polymorphonuclear neutrophils. Detected on cytoplasmic vesicles and lysosomes in immature bone marrow dendritic cells (By similarity). {ECO:0000250|UniProtKB:E9PTA2, ECO:0000250|UniProtKB:Q91YD4}.;
[Isoform 1]: Cell membrane {ECO:0000269|PubMed:11960981, ECO:0000269|PubMed:12594222};
Multi-pass membrane protein {ECO:0000255}.;
[Isoform 2]: Cell membrane {ECO:0000269|PubMed:11960981};
Multi-pass membrane protein {ECO:0000255}.;
[Isoform 3]: Cell membrane {ECO:0000269|PubMed:12594222};
Multi-pass membrane protein {ECO:0000255}.
Mouse PG classificationNA
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