| Gene Information | |
|---|---|
| Gene Name | ABI2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 513 |
| Protein Names | Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000138443 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NYB9 |
| Gene Card | ABI2 |
| Uniprot ID | Q9NYB9 |
| Pfam | PF07815; PF14604 |
| In ASD | no |
| Allosteric Prediction | no (-0.47636654) |
| Ortholog in Animals | Alpaca_ ABI2 ( ortholog_one2one ) Dog_ ABI2 ( ortholog_one2one ) GuineaPig_ ABI2 ( ortholog_one2one ) Macaque_ ABI2 ( ortholog_one2one ) Mouse_ Abi2 ( ortholog_one2one ) Pig_ ABI2 ( ortholog_one2one ) Rat_ Abi2 ( ortholog_one2one ) |
| Ohnologs | ABI3, ABI1 |
| Paralogs | ABI3, ABI1 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Abundant in testes, ovary, thymus, and colon, with lower but detectable levels in prostate, peripheral blood leukocytes, and spleen. {ECO:0000269|PubMed:7590236}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2ED0 (NMR - ) 3P8C (X-ray 2.29A ) 4N78 (X-ray 2.43A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:11516653, ECO:0000269|PubMed:7590236, ECO:0000269|PubMed:8649853}. Nucleus {ECO:0000269|PubMed:7590236}.; [Isoform 1]: Cell projection, lamellipodium {ECO:0000269|PubMed:11516653, ECO:0000269|PubMed:15572692}. Cell projection, filopodium {ECO:0000269|PubMed:11516653}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15572692}. Cell junction, adherens junction {ECO:0000269|PubMed:15572692}. Note=Isoform 1 but not isoform 3 is localized to protruding lamellipodia and filopodia tips (PubMed:11516653, PubMed:15572692). Present at nascent adherens junctions, where it clusters adjacent to the tips of F-actin protrusions (PubMed:15572692). {ECO:0000269|PubMed:11516653, ECO:0000269|PubMed:15572692}. |
| Mouse PG classification | NA |
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