| Gene Information | |
|---|---|
| Gene Name | COL4A1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1669 |
| Protein Names | Collagen alpha-1(IV) chain [Cleaved into: Arresten] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000187498 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P02462 |
| Gene Card | COL4A1 |
| Uniprot ID | P02462 |
| Pfam | PF01413; PF01391 |
| In ASD | no |
| Allosteric Prediction | no (-0.747687797) |
| Ortholog in Animals | Alpaca_ COL4A1 ( ortholog_one2one ) Dog_ COL4A1 ( ortholog_one2one ) GuineaPig_ COL4A1 ( ortholog_one2one ) Macaque_ COL4A1 ( ortholog_one2one ) Mouse_ Col4a1 ( ortholog_one2one ) Pig_ COL4A1 ( ortholog_one2one ) Rat_ Col4a1 ( ortholog_one2one ) Rabbit_ COL4A1 ( ortholog_one2one ) |
| Ohnologs | COL4A6, COL4A3 |
| Paralogs | COL9A2, COLQ, COL17A1, COL1A1, EDA, COL22A1, COL11A1, COL15A1, COL9A3, COL26A1, COL13A1, COL7A1, COL16A1, COL5A1, COL25A1, COL3A1, COL6A2, COL5A3, COL27A1, COL1A2, COL24A1, COL5A2, COL18A1, COL9A1, COL23A1, COL2A1, COL4A2, COL20A1, COL4A4, COL4A6, COL28A1, COL11A2, COL21A1, COL6A1, EMID1, COL4A5, COL4A3 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in placenta. {ECO:0000269|PubMed:10811134, ECO:0000269|PubMed:16481288}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.044400(Mouse);0.002240(Rat);0.025000(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1LI1 (X-ray 1.90A ) 5NAX (X-ray 2.82A ) 5NAY (X-ray 1.80A ) 6MPX (X-ray 1.90A ) |
| DBSNP | rs9515185 rs34843786 rs200786329 rs267606744 rs113994104 rs267606743 rs113994105 rs281865426 rs113994106 rs397514624 rs536174 rs121912857 rs672601349 rs113994108 rs113994109 rs672601346 rs672601347 rs113994110 rs1877962670 rs1555303073 rs113994111 rs113994112 rs587777379 rs1877331560 rs3742207 rs113994113 rs1343193102 rs113994114 rs1876543576 rs672601348 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250|UniProtKB:P02463}. |
| Mouse PG classification | HPG |
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