| Gene Information | |
|---|---|
| Gene Name | AP2S1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 142 |
| Protein Names | AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (HA2 17 kDa subunit) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000042753 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P53680 |
| Gene Card | AP2S1 |
| Uniprot ID | P53680 |
| Pfam | PF01217 |
| In ASD | no |
| Allosteric Prediction | no (-0.118572256) |
| Ortholog in Animals | Alpaca_ AP2S1 ( ortholog_one2one ) Dog_ AP2S1 ( ortholog_one2one ) GuineaPig_ AP2S1 ( ortholog_one2one ) Macaque_ AP2S1 ( ortholog_one2one ) Mouse_ Ap2s1 ( ortholog_one2one ) Pig_ AP2S1 ( ortholog_one2one ) Rat_ Ap2s1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | AP1S1, AP1S2, AP1S3, AP3S1, AP3S2, AP4S1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6URI (X-ray 3.00A ) |
| DBSNP | rs397514498 rs397514499 rs397514499 |
| Subcellular location [CC] | Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV. {ECO:0000250}. |
| Mouse PG classification | NA |
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