Gene Information
Gene NameMTHFD2
OrganismHomo sapiens (Human)
Gene Length350
Protein NamesBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)]
Target Namebifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
Target TypeNA
Gene Age382 ( ENSG00000065911 )
Evolutionary StageCellular_organisms
AlphaFoldDBP13995
Gene CardMTHFD2
Uniprot IDP13995
PfamPF00763; PF02882
In ASDyes
Allosteric Predictionyes (0.533050425)
Ortholog in AnimalsAlpaca_ MTHFD2 ( ortholog_one2one )
Dog_ MTHFD2 ( ortholog_one2many )
GuineaPig_ MTHFD2 ( ortholog_one2one )
Macaque_ MTHFD2 ( ortholog_one2one )
Mouse_ Mthfd2 ( ortholog_one2one )
Pig_ MTHFD2 ( ortholog_one2one )
Rat_ Mthfd2 ( ortholog_one2one )
OhnologsMTHFD2L
ParalogsMTHFD2L, MTHFD1L, MTHFD1
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 5TC4  (X-ray  1.89A  )  6JIB  (X-ray  2.25A  )  6JID  (X-ray  2.50A  )  6KG2  (X-ray  2.25A  )  6S4A  (X-ray  1.95A  )  6S4E  (X-ray  1.90A  )  6S4F  (X-ray  2.20A  )  7EHJ  (X-ray  2.16A  )  7EHM  (X-ray  2.13A  )  7EHN  (X-ray  2.25A  )  7EHV  (X-ray  2.61A  ) 
DBSNP NA 
Subcellular location [CC]Mitochondrion.
Mouse PG classificationNA
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