| Gene Information | |
|---|---|
| Gene Name | BDKRB2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 391 |
| Protein Names | B2 bradykinin receptor (B2R) (BK-2 receptor) |
| Target Name | b2 bradykinin receptor |
| Target Type | Successful target |
| Gene Age | 645 ( ENSG00000168398 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P30411 |
| Gene Card | BDKRB2 |
| Uniprot ID | P30411 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.600913764) |
| Ortholog in Animals | Alpaca_ BDKRB2 ( ortholog_one2one ) Dog_ BDKRB2 ( ortholog_one2one ) GuineaPig_ BDKRB2 ( ortholog_one2one ) Macaque_ BDKRB2 ( ortholog_one2one ) Mouse_ Bdkrb2 ( ortholog_one2one ) Pig_ BDKRB2 ( ortholog_one2one ) Rat_ Bdkrb2 ( ortholog_one2one ) Rabbit_ BDKRB2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | BDKRB1, RXFP4, GPR15, AGTR2, GPR25, APLNR, AGTR1 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Widespread in normal smooth muscle tissue and neurons. {ECO:0000269|PubMed:7835885}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7F2O (EM 2.90A ) 7F6H (EM 2.90A ) 7F6I (EM 2.80A ) |
| DBSNP | rs1046248 rs2227279 |
| Subcellular location [CC] | Cell membrane {ECO:0000305|PubMed:1314587}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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