| Gene Information | |
|---|---|
| Gene Name | TRIM8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 551 |
| Protein Names | E3 ubiquitin-protein ligase TRIM8 (EC 2.3.2.27) (Glioblastoma-expressed RING finger protein) (RING finger protein 27) (RING-type E3 ubiquitin transferase TRIM8) (Tripartite motif-containing protein 8) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000171206 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9BZR9 |
| Gene Card | TRIM8 |
| Uniprot ID | Q9BZR9 |
| Pfam | PF00097 |
| In ASD | no |
| Allosteric Prediction | no (-0.550276276) |
| Ortholog in Animals | Alpaca_ TRIM8 ( ortholog_one2one ) Dog_ TRIM8 ( ortholog_one2one ) GuineaPig_ TRIM8 ( ortholog_one2one ) Macaque_ TRIM8 ( ortholog_one2one ) Mouse_ Trim8 ( ortholog_one2one ) Pig_ TRIM8 ( ortholog_one2one ) Rat_ Trim8 ( ortholog_one2one ) Rabbit_ TRIM8 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TRIM42, TRIM13, TRIM31, TRIM49B, TRIM49C, TRIM49, TRIM33, TRIM69, TRIM71, TRIM77, TRIM28, TRIM3, TRIM46, TRIM58, TRIM38, TRIM5, TRIM37, MID1, TRIM7, TRIM36, TRIM44, TRIML2, TRIM2, TRIM63, TRIM73, TRIM74, TRIM65, TRIML1, MID2, TRIM32, TRIM14, TRIM34, TRIM54, TRIM55, TRIM52, TRIM41, TRIM11, PML, TRIM43, TRIM43B, TRIM21, TRIM6, TRIM27, TRIM40, TRIM51G, TRIM51, TRIM9, TRIM67, TRIM25, TRIM49D1, TRIM48, TRIM49D2, TRIM68, TRIM17, TRIM24, TRIM64C, TRIM64, TRIM64B, TRIM60, TRIM61, TRIM4, TRIM10, BSPRY, TRIM56, TRIM29, MEFV, TRIM15, TRIM22, TRIM35, TRIM16, TRIM47, TRIM45, TRIM72, TRIM62, TRIM50, TRIM75, TRIM66, RNF39, TRIM26, TRIM39 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Expressed in glomerular podocytes of kidneys. {ECO:0000269|PubMed:33508234, ECO:0000305}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:23152791}. Nucleus {ECO:0000269|PubMed:23152791}. Nucleus, nuclear body {ECO:0000269|PubMed:33508234}. Note=Nucleo-cytoplasmic translocation is involved in regulation of NF-kappa-B. {ECO:0000269|PubMed:23152791}. |
| Mouse PG classification | NA |
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