| Gene Information | |
|---|---|
| Gene Name | TNFRSF1A |
| Organism | Homo sapiens (Human) |
| Gene Length | 455 |
| Protein Names | Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)] |
| Target Name | tumor necrosis factor receptor superfamily member 1a |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000067182 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P19438 |
| Gene Card | TNFRSF1A |
| Uniprot ID | P19438 |
| Pfam | PF00531; PF00020 |
| In ASD | yes |
| Allosteric Prediction | yes (1.0003874) |
| Ortholog in Animals | Alpaca_ TNFRSF1A ( ortholog_one2one ) GuineaPig_ TNFRSF1A ( ortholog_one2one ) Macaque_ TNFRSF1A ( ortholog_one2one ) Mouse_ Tnfrsf1a ( ortholog_one2one ) Pig_ TNFRSF1A ( ortholog_one2one ) Rat_ Tnfrsf1a ( ortholog_one2one ) Rabbit_ TNFRSF1A ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TNFRSF25, TNFRSF6B, CD40, TNFRSF21, TNFRSF10C, TNFRSF11B, TNFRSF10B, TNFRSF11A, CD27, NGFR, FAS, TNFRSF10A, TNFRSF9, TNFRSF18, TNFRSF8, LTBR, RELT, TNFRSF10D, TNFRSF4, TNFRSF14, TNFRSF1B |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1EXT (X-ray 1.85A ) 1FT4 (X-ray 2.90A ) 1ICH (NMR - ) 1NCF (X-ray 2.25A ) 1TNR (X-ray 2.85A ) 7K7A (NMR - ) 7KP7 (X-ray 2.65A ) 7KP8 (X-ray 3.15A ) 7KPB (X-ray 3.00A ) |
| DBSNP | rs104895254 rs104895217 rs104895223 rs104895225 rs104895218 rs4149637 rs104895219 rs104895220 rs104895228 rs104895221 rs104895222 rs4149584 rs4149584 rs1804532 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:22801493}; Single-pass type I membrane protein {ECO:0000269|PubMed:22801493}. Golgi apparatus membrane {ECO:0000269|PubMed:22801493}; Single-pass type I membrane protein {ECO:0000269|PubMed:22801493}. Secreted {ECO:0000269|PubMed:22801493}. Note=A secreted form is produced through proteolytic processing.; [Isoform 4]: Secreted. Note=Lacks a Golgi-retention motif, is not membrane bound and therefore is secreted. |
| Mouse PG classification | LPG |
| click here to return to the previous page | |