| Gene Information | |
|---|---|
| Gene Name | CD53 |
| Organism | Homo sapiens (Human) |
| Gene Length | 219 |
| Protein Names | Leukocyte surface antigen CD53 (Cell surface glycoprotein CD53) (Tetraspanin-25) (Tspan-25) (CD antigen CD53) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000143119 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P19397 |
| Gene Card | CD53 |
| Uniprot ID | P19397 |
| Pfam | PF00335 |
| In ASD | no |
| Allosteric Prediction | no (-0.628952812) |
| Ortholog in Animals | Alpaca_ CD53 ( ortholog_one2one ) Dog_ CD53 ( ortholog_one2one ) GuineaPig_ CD53 ( ortholog_one2one ) Macaque_ CD53 ( ortholog_one2one ) Mouse_ Cd53 ( ortholog_one2one ) Pig_ CD53 ( ortholog_one2one ) Rat_ Cd53 ( ortholog_one2one ) Rabbit_ CD53 ( ortholog_one2one ) |
| Ohnologs | TSPAN9, CD82, TSPAN11, TSPAN4 |
| Paralogs | ROM1, TSPAN12, CD63, TSPAN10, CD9, TSPAN6, TSPAN5, CD37, CD151, TSPAN4, TSPAN1, TSPAN31, UPK1A, TSPAN17, TSPAN11, TSPAN32, TSPAN8, TSPAN13, TSPAN2, TSPAN9, TSPAN18, CD81, CD82, TSPAN16, TSPAN19, TSPAN7, UPK1B, TSPAN3, TSPAN14, TSPAN15, PRPH2, TSPAN33 |
| Tissue | NA |
| Tissue Specificity | B-cells, monocytes, macrophages, neutrophils, single (CD4 or CD8) positive thymocytes and peripheral T-cells. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6WVG (X-ray 2.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000250}. Cell junction {ECO:0000250}. Membrane; Multi-pass membrane protein. Note=Concentrates in localized microdomains along the plasma membrane at the contact sites between cells of fused myotubes. {ECO:0000250}. |
| Mouse PG classification | NA |
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