Gene Information
Gene NameTRIM5
OrganismHomo sapiens (Human)
Gene Length493
Protein NamesTripartite motif-containing protein 5 (EC 2.3.2.27) (RING finger protein 88) (RING-type E3 ubiquitin transferase TRIM5)
Target NameNA
Target TypeNA
Gene Age382 ( ENSG00000132256 )
Evolutionary StageEukaryota
AlphaFoldDBQ9C035
Gene CardTRIM5
Uniprot IDQ9C035
PfamPF00622; PF00643; PF13445
In ASDno
Allosteric Predictionno (-0.24541372)
Ortholog in AnimalsAlpaca_ TRIM5 ( ortholog_one2one )
Macaque_ TRIM5 ( ortholog_one2one )
Mouse_ Trim30c ( ortholog_one2many )
Mouse_ Trim30b ( ortholog_one2many )
Mouse_ Trim5 ( ortholog_one2many )
Mouse_ Trim30d ( ortholog_one2many )
Mouse_ Trim12c ( ortholog_one2many )
Mouse_ Trim12a ( ortholog_one2many )
Mouse_ Trim30a ( ortholog_one2many )
Rat_ Trim30c ( ortholog_one2many )
Rat_ Trim5 ( ortholog_one2many )
Rabbit_ TRIM5 ( ortholog_one2one )
OhnologsNA
ParalogsTRIM42, TRIM13, TRIM31, TRIM49B, TRIM49C, TRIM49, TRIM33, TRIM69, TRIM71, TRIM77, TRIM28, TRIM3, TRIM46, TRIM58, TRIM38, TRIM37, MID1, TRIM7, TRIM36, TRIM44, TRIML2, TRIM2, TRIM63, TRIM73, TRIM74, TRIM65, TRIML1, MID2, TRIM32, TRIM14, TRIM34, TRIM54, TRIM55, TRIM52, TRIM41, TRIM11, PML, TRIM43, TRIM43B, TRIM21, TRIM6, TRIM27, TRIM40, TRIM51G, TRIM51, TRIM9, TRIM67, TRIM25, TRIM49D1, TRIM48, TRIM49D2, TRIM68, TRIM17, TRIM24, TRIM64C, TRIM64, TRIM64B, TRIM60, TRIM61, TRIM4, TRIM10, BSPRY, TRIM56, TRIM29, TRIM8, MEFV, TRIM15, TRIM22, TRIM35, TRIM16, TRIM47, TRIM45, TRIM72, TRIM62, TRIM50, TRIM75, TRIM66, RNF39, TRIM26, TRIM39
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2ECV  (NMR  2YRG  (NMR 
DBSNP rs59896509  rs3740996  rs61432120  rs56348930  rs11601507  rs10838525  rs11038628  rs28381981  rs59218593  rs7104422 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:25127057}. Nucleus {ECO:0000250|UniProtKB:Q0PF16}. Note=Predominantly localizes in cytoplasmic bodies (PubMed:12878161, PubMed:20357094). Localization may be influenced by the coexpression of other TRIM proteins, hence partial nuclear localization is observed in the presence of TRIM22 or TRIM27 (By similarity). In cytoplasmic bodies, colocalizes with proteasomal subunits and SQSTM1 (By similarity). {ECO:0000250|UniProtKB:Q0PF16, ECO:0000269|PubMed:12878161, ECO:0000269|PubMed:20357094, ECO:0000269|PubMed:25127057}.
Mouse PG classificationNA
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