| Gene Information | |
|---|---|
| Gene Name | TRIM39 |
| Organism | Homo sapiens (Human) |
| Gene Length | 518 |
| Protein Names | E3 ubiquitin-protein ligase TRIM39 (EC 2.3.2.27) (RING finger protein 23) (RING-type E3 ubiquitin transferase TRIM39) (Testis-abundant finger protein) (Tripartite motif-containing protein 39) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000204599 ) 3 ( ENSG00000206495 ) 3 ( ENSG00000224994 ) 3 ( ENSG00000226437 ) 3 ( ENSG00000229929 ) 3 ( ENSG00000230308 ) 3 ( ENSG00000232839 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q9HCM9 |
| Gene Card | TRIM39 |
| Uniprot ID | Q9HCM9 |
| Pfam | PF13765; PF00622; PF00643 |
| In ASD | no |
| Allosteric Prediction | no (-0.762404994) |
| Ortholog in Animals | Alpaca_ TRIM39 ( ortholog_one2one ) GuineaPig_ TRIM39 ( ortholog_one2one ) Macaque_ TRIM39 ( ortholog_one2one ) Mouse_ Trim39 ( ortholog_one2one ) Pig_ TRIM39 ( ortholog_one2one ) Rat_ Trim39 ( ortholog_one2one ) Rabbit_ TRIM39 ( ortholog_one2one ) |
| Ohnologs | TRIM73 |
| Paralogs | TRIM42, TRIM13, TRIM31, TRIM49B, TRIM49C, TRIM49, TRIM33, TRIM69, TRIM71, TRIM77, TRIM28, TRIM3, TRIM46, TRIM58, TRIM38, TRIM5, TRIM37, MID1, TRIM7, TRIM36, TRIM44, TRIML2, TRIM2, TRIM63, TRIM73, TRIM74, TRIM65, TRIML1, MID2, TRIM32, TRIM14, TRIM34, TRIM54, TRIM55, TRIM52, TRIM41, TRIM11, PML, TRIM43, TRIM43B, TRIM21, TRIM6, TRIM27, TRIM40, TRIM51G, TRIM51, TRIM9, TRIM67, TRIM25, TRIM49D1, TRIM48, TRIM49D2, TRIM68, TRIM17, TRIM24, TRIM64C, TRIM64, TRIM64B, TRIM60, TRIM61, TRIM4, TRIM10, BSPRY, TRIM56, TRIM29, TRIM8, MEFV, TRIM15, TRIM22, TRIM35, TRIM16, TRIM47, TRIM45, TRIM72, TRIM62, TRIM50, TRIM75, TRIM66, RNF39, TRIM26 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous; highly expressed in brain, heart, kidney, liver, skeletal muscle, spleen and testis. {ECO:0000269|PubMed:19100260}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2DID (NMR - ) 2DIF (NMR - ) 2ECJ (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | [Isoform 1]: Cytoplasm, cytosol {ECO:0000269|PubMed:19100260}. Mitochondrion {ECO:0000269|PubMed:19100260}. Nucleus {ECO:0000269|PubMed:23213251}. Note=Found predominantly in the cytosol. Partial shift from the cytosol to the mitochondria when colocalized with MOAP1. Colocalizes with CDKN1A in the nucleus. {ECO:0000269|PubMed:19100260, ECO:0000269|PubMed:23213251}.; [Isoform 2]: Nucleus {ECO:0000269|PubMed:23213251}. Note=Colocalizes with CDKN1A in the nucleus. {ECO:0000269|PubMed:23213251}. |
| Mouse PG classification | NA |
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