| Gene Information | |
|---|---|
| Gene Name | PDE4A |
| Organism | Homo sapiens (Human) |
| Gene Length | 886 |
| Protein Names | cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) |
| Target Name | phosphodiesterase 4a |
| Target Type | Successful target |
| Gene Age | 680 ( ENSG00000065989 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P27815 |
| Gene Card | PDE4A |
| Uniprot ID | P27815 |
| Pfam | PF18100; PF00233 |
| In ASD | yes |
| Allosteric Prediction | yes (1.223850537) |
| Ortholog in Animals | Alpaca_ PDE4A ( ortholog_one2one ) Dog_ PDE4A ( ortholog_one2one ) GuineaPig_ PDE4A ( ortholog_one2one ) Macaque_ PDE4A ( ortholog_one2one ) Mouse_ Pde4a ( ortholog_one2one ) Pig_ PDE4A ( ortholog_one2one ) Rat_ Pde4a ( ortholog_one2one ) Rabbit_ PDE4A ( ortholog_one2one ) |
| Ohnologs | PDE4C, PDE4D, PDE4B |
| Paralogs | PDE8A, PDE4D, PDE4B, PDE6A, PDE2A, PDE6C, PDE8B, PDE1B, PDE9A, PDE10A, PDE1A, PDE7A, PDE3B, PDE1C, PDE11A, PDE5A, PDE3A, PDE7B, PDE6B, PDE4C |
| Tissue | NA |
| Tissue Specificity | [Isoform 1]: Expressed in lymphoid cell subsets including CD8-positive T cells and T-helper 2 cells. Expressed in dendritic cells. {ECO:0000269|PubMed:15738310}.; [Isoform 2]: Highly expressed in liver, stomach, testis, thyroid and adrenal glands and at a lower extent in placenta, kidney, pancreas, ovary, uterus and skin. Expressed in myeloid cell subsets including dendritic cells, monocytes, macrophages, eosinophils and mast cells. Expressed in natural killer cells. Expressed in bronchial smooth muscle. {ECO:0000269|PubMed:15738310}.; [Isoform 6]: Expressed at high levels in the heart and small intestine. It is also found in the brain, kidney, spleen, colon, salivary gland, ovary and peripheral blood lymphocytes. {ECO:0000269|PubMed:11306681}.; [Isoform 7]: Expressed predominantly in skeletal muscle and brain and at lower levels in the testis. Found in specific neuronal subpopulations including cortical pyramidal neurons, horn neurons in the spinal cord and Purkinje cells in cerebellum (at protein level). {ECO:0000269|PubMed:18095939}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2QYK (X-ray 2.10A ) 3I8V (X-ray 2.25A ) 3TVX (X-ray 2.84A ) |
| DBSNP | rs1051738 rs2230190 |
| Subcellular location [CC] | [Isoform 1]: Cytoplasm, perinuclear region {ECO:0000269|PubMed:15738310}.; [Isoform 2]: Cytoplasm, perinuclear region {ECO:0000269|PubMed:15738310}. Cell projection, ruffle membrane {ECO:0000269|PubMed:15738310}.; [Isoform 3]: Cytoplasm, cytosol {ECO:0000269|PubMed:7888306}.; [Isoform 4]: Membrane; Peripheral membrane protein {ECO:0000269|PubMed:9677330}. Note=Isoform 4 has propensity for association with membranes. {ECO:0000269|PubMed:9677330}.; [Isoform 6]: Cytoplasm, perinuclear region {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}.; [Isoform 7]: Cytoplasm, cytosol. Membrane; Peripheral membrane protein {ECO:0000269|PubMed:18095939}. Note=Predominantly cytosolic. {ECO:0000269|PubMed:18095939}. |
| Mouse PG classification | NA |
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