| Gene Information | |
|---|---|
| Gene Name | TRIM34 |
| Organism | Homo sapiens (Human) |
| Gene Length | 488 |
| Protein Names | E3 ubiquitin-protein ligase TRIM34 (EC 2.3.2.27) (Interferon-responsive finger protein 1) (RING finger protein 21) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000258659 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q9BYJ4 |
| Gene Card | TRIM34 |
| Uniprot ID | Q9BYJ4 |
| Pfam | PF00622; PF00643 |
| In ASD | no |
| Allosteric Prediction | no (-1.053694608) |
| Ortholog in Animals | Alpaca_ TRIM6 ( ortholog_one2one ) GuineaPig_ TRIM34 ( ortholog_one2one ) Mouse_ Trim34a ( ortholog_one2many ) Mouse_ Trim34b ( ortholog_one2many ) Pig_ TRIM34 ( ortholog_one2one ) Rat_ Trim34 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TRIM42, TRIM13, TRIM31, TRIM49B, TRIM49C, TRIM49, TRIM33, TRIM69, TRIM71, TRIM77, TRIM28, TRIM3, TRIM46, TRIM58, TRIM38, TRIM5, TRIM37, MID1, TRIM7, TRIM36, TRIM44, TRIML2, TRIM2, TRIM63, TRIM73, TRIM74, TRIM65, TRIML1, MID2, TRIM32, TRIM14, TRIM54, TRIM55, TRIM52, TRIM41, TRIM11, PML, TRIM43, TRIM43B, TRIM21, TRIM6, TRIM27, TRIM40, TRIM51G, TRIM51, TRIM9, TRIM67, TRIM25, TRIM49D1, TRIM48, TRIM49D2, TRIM68, TRIM17, TRIM24, TRIM64C, TRIM64, TRIM64B, TRIM60, TRIM61, TRIM4, TRIM10, BSPRY, TRIM56, TRIM29, TRIM8, MEFV, TRIM15, TRIM22, TRIM35, TRIM16, TRIM47, TRIM45, TRIM72, TRIM62, TRIM50, TRIM75, TRIM66, RNF39, TRIM26, TRIM39 |
| Tissue | NA |
| Tissue Specificity | [Isoform 1]: Is the most abundant form. It is highly expressed in the placenta, spleen, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:11013086}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2EGP (NMR - ) |
| DBSNP | rs6578670 rs3740997 rs16933844 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17156811, ECO:0000269|PubMed:31487507, ECO:0000269|PubMed:32282853}. Mitochondrion {ECO:0000269|PubMed:31956709}. Note=Localizes in cytoplasmic bodies together with TRIM5 and incoming HIV-1 capsids during infection. {ECO:0000269|PubMed:32282853}. |
| Mouse PG classification | NA |
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