| Gene Information | |
|---|---|
| Gene Name | PDGFB |
| Organism | Homo sapiens (Human) |
| Gene Length | 241 |
| Protein Names | Platelet-derived growth factor subunit B (PDGF subunit B) (PDGF-2) (Platelet-derived growth factor B chain) (Platelet-derived growth factor beta polypeptide) (Proto-oncogene c-Sis) (Becaplermin) |
| Target Name | platelet-derived growth factor subunit b |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000100311 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P01127 |
| Gene Card | PDGFB |
| Uniprot ID | P01127 |
| Pfam | PF00341; PF04692 |
| In ASD | no |
| Allosteric Prediction | yes (0.261304681) |
| Ortholog in Animals | Alpaca_ PDGFB ( ortholog_one2one ) Dog_ PDGFB ( ortholog_one2one ) GuineaPig_ PDGFB ( ortholog_one2one ) Macaque_ PDGFB ( ortholog_one2one ) Mouse_ Pdgfb ( ortholog_one2one ) Pig_ PDGFB ( ortholog_one2one ) Rat_ Pdgfb ( ortholog_one2one ) Rabbit_ PDGFB ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PDGFA |
| Tissue | NA |
| Tissue Specificity | Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung. {ECO:0000269|PubMed:11331882}. |
| Pharmacological Animal Models | 0.087880(Chimpanzee);0.070650(Mouse);0.002990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1PDG (X-ray 3.00A ) 3MJG (X-ray 2.30A ) 4HQU (X-ray 2.20A ) 4HQX (X-ray 2.30A ) 4QCI (X-ray 2.30A ) 6T9E (X-ray 2.99A ) |
| DBSNP | rs17565 rs397515632 |
| Subcellular location [CC] | Secreted. Note=Released by platelets upon wounding. |
| Mouse PG classification | LPG |
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