| Gene Information | |
|---|---|
| Gene Name | TRIM28 |
| Organism | Homo sapiens (Human) |
| Gene Length | 835 |
| Protein Names | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 424 ( ENSG00000130726 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q13263 |
| Gene Card | TRIM28 |
| Uniprot ID | Q13263 |
| Pfam | PF00628; PF00643; PF14634 |
| In ASD | no |
| Allosteric Prediction | no (-0.872004762) |
| Ortholog in Animals | Alpaca_ TRIM28 ( ortholog_one2one ) Dog_ TRIM28 ( ortholog_one2one ) Macaque_ TRIM28 ( ortholog_one2one ) Mouse_ Trim28 ( ortholog_one2one ) Pig_ TRIM28 ( ortholog_one2one ) Rat_ Trim28 ( ortholog_one2one ) Rabbit_ TRIM28 ( ortholog_one2one ) |
| Ohnologs | TRIM24 |
| Paralogs | TRIM42, TRIM13, TRIM31, TRIM49B, TRIM49C, TRIM49, TRIM33, TRIM69, TRIM71, TRIM77, TRIM3, TRIM46, TRIM58, TRIM38, TRIM5, TRIM37, MID1, TRIM7, TRIM36, TRIM44, TRIML2, TRIM2, TRIM63, TRIM73, TRIM74, TRIM65, TRIML1, MID2, TRIM32, TRIM14, TRIM34, TRIM54, TRIM55, TRIM52, TRIM41, TRIM11, PML, TRIM43, TRIM43B, TRIM21, TRIM6, TRIM27, TRIM40, TRIM51G, TRIM51, TRIM9, TRIM67, TRIM25, TRIM49D1, TRIM48, TRIM49D2, TRIM68, TRIM17, TRIM24, TRIM64C, TRIM64, TRIM64B, TRIM60, TRIM61, TRIM4, TRIM10, BSPRY, TRIM56, TRIM29, TRIM8, MEFV, TRIM15, TRIM22, TRIM35, TRIM16, TRIM47, TRIM45, TRIM72, TRIM62, TRIM50, TRIM75, TRIM66, RNF39, TRIM26, TRIM39 |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues tested including spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:9016654}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001430(Rat);0.017021(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1FP0 (NMR - ) 2RO1 (NMR - ) 2YVR (X-ray 1.80A ) 6H3A (X-ray 5.50A ) 6I9H (NMR - ) 6QAJ (X-ray 2.90A ) 6QU1 (X-ray 3.70A ) |
| DBSNP | rs56229738 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10330177, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24741090, ECO:0000269|PubMed:9016654}. Note=Associated with centromeric heterochromatin during cell differentiation through CBX1. {ECO:0000250|UniProtKB:Q62318}. |
| Mouse PG classification | NA |
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