| Gene Information | |
|---|---|
| Gene Name | TRIM24 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1050 |
| Protein Names | Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24) |
| Target Name | tripartite motif-containing 24 |
| Target Type | Literature-reported target |
| Gene Age | 454 ( ENSG00000122779 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O15164 |
| Gene Card | TRIM24 |
| Uniprot ID | O15164 |
| Pfam | PF00439; PF00628; PF00643 |
| In ASD | no |
| Allosteric Prediction | yes (0.445104976) |
| Ortholog in Animals | Alpaca_ TRIM24 ( ortholog_one2one ) Dog_ TRIM24 ( ortholog_one2many ) GuineaPig_ TRIM24 ( ortholog_one2one ) Macaque_ TRIM24 ( ortholog_one2one ) Mouse_ Trim24 ( ortholog_one2one ) Pig_ TRIM24 ( ortholog_one2one ) Rat_ Trim24 ( ortholog_one2one ) Rabbit_ TRIM24 ( ortholog_one2one ) |
| Ohnologs | TRIM28, TRIM33 |
| Paralogs | TRIM42, TRIM13, TRIM31, TRIM49B, TRIM49C, TRIM49, TRIM33, TRIM69, TRIM71, TRIM77, TRIM28, TRIM3, TRIM46, TRIM58, TRIM38, TRIM5, TRIM37, MID1, TRIM7, TRIM36, TRIM44, TRIML2, TRIM2, TRIM63, TRIM73, TRIM74, TRIM65, TRIML1, MID2, TRIM32, TRIM14, TRIM34, TRIM54, TRIM55, TRIM52, TRIM41, TRIM11, PML, TRIM43, TRIM43B, TRIM21, TRIM6, TRIM27, TRIM40, TRIM51G, TRIM51, TRIM9, TRIM67, TRIM25, TRIM49D1, TRIM48, TRIM49D2, TRIM68, TRIM17, TRIM64C, TRIM64, TRIM64B, TRIM60, TRIM61, TRIM4, TRIM10, BSPRY, TRIM56, TRIM29, TRIM8, MEFV, TRIM15, TRIM22, TRIM35, TRIM16, TRIM47, TRIM45, TRIM72, TRIM62, TRIM50, TRIM75, TRIM66, RNF39, TRIM26, TRIM39 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2YYN (X-ray 2.50A ) 3O33 (X-ray 2.00A ) 3O34 (X-ray 1.90A ) 3O35 (X-ray 1.76A ) 3O36 (X-ray 1.70A ) 3O37 (X-ray 2.00A ) 4YAB (X-ray 1.90A ) 4YAD (X-ray 1.73A ) 4YAT (X-ray 2.18A ) 4YAX (X-ray 2.25A ) 4YBM (X-ray 1.46A ) 4YBS (X-ray 1.83A ) 4YBT (X-ray 1.82A ) 4YC9 (X-ray 1.82A ) 4ZQL (X-ray 1.79A ) 5H1T (X-ray 1.95A ) 5H1U (X-ray 1.90A ) 5H1V (X-ray 2.00A ) 7B9X (NMR - ) |
| DBSNP | rs35356723 rs34585297 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:21164480, ECO:0000269|PubMed:32324863}. Cytoplasm {ECO:0000269|PubMed:21164480}. Mitochondrion {ECO:0000269|PubMed:32324863}. Note=Colocalizes with sites of active transcription. Detected both in nucleus and cytoplasm in some breast cancer samples. Predominantly nuclear. Translocated from nucleus to mitochondria to mediate antiviral immunity (PubMed:32324863). {ECO:0000269|PubMed:32324863}. |
| Mouse PG classification | NA |
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