| Gene Information | |
|---|---|
| Gene Name | TRF |
| Organism | Homo sapiens (Human) |
| Gene Length | 439 |
| Protein Names | Telomeric repeat-binding factor 1 (NIMA-interacting protein 2) (TTAGGG repeat-binding factor 1) (Telomeric protein Pin2/TRF1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P54274 |
| Gene Card | TERF1 |
| Uniprot ID | P54274 |
| Pfam | PF00249; PF08558 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed and ubiquitous. Isoform Pin2 predominates. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.004927(Rat);0.063251(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1BA5 (NMR - ) 1H6O (X-ray 2.90A ) 1ITY (NMR - ) 1IV6 (NMR - ) 1W0T (X-ray 2.00A ) 3BQO (X-ray 2.00A ) 3L82 (X-ray 2.40A ) 5HKP (X-ray 2.20A ) 5WIR (X-ray 2.10A ) 5XUP (X-ray 2.10A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, telomere. Note=Colocalizes with telomeric DNA in interphase and prophase cells. Telomeric localization decreases in metaphase, anaphase and telophase. Associates with the mitotic spindle. |
| Mouse PG classification | NA |
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