| Gene Information | |
|---|---|
| Gene Name | TREX1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 314 |
| Protein Names | Three-prime repair exonuclease 1 (EC 3.1.11.2) (3'-5' exonuclease TREX1) (Deoxyribonuclease III) (DNase III) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 18 ( ENSG00000213689 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NSU2 |
| Gene Card | TREX1 |
| Uniprot ID | Q9NSU2 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.175159731) |
| Ortholog in Animals | Alpaca_ TREX1 ( ortholog_one2one ) Dog_ TREX1 ( ortholog_one2one ) GuineaPig_ TREX1 ( ortholog_one2one ) Macaque_ TREX1 ( ortholog_one2one ) Mouse_ Trex1 ( ortholog_one2one ) Pig_ TREX1 ( ortholog_one2one ) Rat_ Trex1 ( ortholog_one2one ) Rabbit_ TREX1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TREX2 |
| Tissue | NA |
| Tissue Specificity | Detected in thymus, spleen, liver, brain, heart, small intestine and colon. {ECO:0000269|PubMed:10393201, ECO:0000269|PubMed:11278605}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 7TQN (X-ray 1.80A ) 7TQO (X-ray 1.25A ) 7TQP (X-ray 1.95A ) 7TQQ (X-ray 2.20A ) |
| DBSNP | rs121908117 rs72556554 rs79993407 rs762011967 rs1416519719 rs78846775 rs78408272 rs113107733 rs72556555 rs112741962 rs55999987 rs148833270 rs76224909 rs370504038 rs780022923 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10393201}. Cytoplasm, cytosol {ECO:0000269|PubMed:16818237}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:33476576}; Peripheral membrane protein {ECO:0000269|PubMed:33476576}. Note=Retained in the cytoplasm through the C-terminal region (By similarity). Localization to the endoplasmic reticulum membrane is required to direct TREX1 to ruptured micronuclei (PubMed:33476576). In response to DNA damage, translocates to the nucleus where it is specifically recruited to replication foci (PubMed:16818237). Translocation to the nucleus also occurs during GZMA-mediated cell death (PubMed:16818237). {ECO:0000250|UniProtKB:Q91XB0, ECO:0000269|PubMed:16818237, ECO:0000269|PubMed:33476576}. |
| Mouse PG classification | NA |
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