Gene Information
Gene NameTREM1
OrganismHomo sapiens (Human)
Gene Length234
Protein NamesTriggering receptor expressed on myeloid cells 1 (TREM-1) (Triggering receptor expressed on monocytes 1) (CD antigen CD354)
Target Nametriggering receptor expressed on myeloid cells 1
Target TypeNA
Gene Age424 ( ENSG00000124731 )
Evolutionary StageVertebrata
AlphaFoldDBQ9NP99
Gene CardTREM1
Uniprot IDQ9NP99
PfamPF07686
In ASDno
Allosteric Predictionno (-0.265433789)
Ortholog in AnimalsDog_ TREM1 ( ortholog_one2one )
Macaque_ TREM1 ( ortholog_one2one )
Mouse_ Trem1 ( ortholog_one2one )
Pig_ TREM1 ( ortholog_one2one )
Rat_ Trem1 ( ortholog_one2one )
OhnologsNA
ParalogsNA
Tissueappendix, bone.marrow, lung, whole.blood
Tissue SpecificityMostly expressed by immune cells of the myeloid lineage, such as monocytes, macrophages, neutrophils and dendritic cells (PubMed:10799849). Expression is associated with a mature stage of myeloid development (PubMed:11922939). Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Isoform 2 was detected in the lung, liver and mature monocytes. {ECO:0000269|PubMed:10799849, ECO:0000269|PubMed:11922939, ECO:0000269|PubMed:21393102}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1Q8M  (X-ray  2.60A  )  1SMO  (X-ray  1.47A  ) 
DBSNP rs2234237  rs34727391  rs2234245 
Subcellular location [CC][Isoform 1]: Cell membrane {ECO:0000269|PubMed:17098818, ECO:0000269|PubMed:21393102};
Single-pass type I membrane protein {ECO:0000305}. Note=Recruited to lipid rafts when activated. {ECO:0000269|PubMed:17098818}.;
[Isoform 2]: Secreted {ECO:0000269|PubMed:26561551}.
Mouse PG classificationNA
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