Gene Information
Gene NameTRAP1
OrganismHomo sapiens (Human)
Gene Length704
Protein NamesHeat shock protein 75 kDa, mitochondrial (HSP 75) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1)
Target NameNA
Target TypeNA
Gene Age>4290 ( ENSG00000126602 )
Evolutionary StageEuk+Bac
AlphaFoldDBQ12931
Gene CardTRAP1
Uniprot IDQ12931
PfamPF00183
In ASDyes
Allosteric Predictionno (-0.227593882)
Ortholog in AnimalsAlpaca_ TRAP1 ( ortholog_one2one )
Dog_ TRAP1 ( ortholog_one2one )
GuineaPig_ TRAP1 ( ortholog_one2one )
Macaque_ TRAP1 ( ortholog_one2one )
Mouse_ Trap1 ( ortholog_one2one )
Pig_ TRAP1 ( ortholog_one2one )
Rat_ Trap1 ( ortholog_one2one )
OhnologsNA
ParalogsHSP90B1, HSP90AA1, HSP90AB1
TissueNA
Tissue SpecificityFound in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, placenta and bladder. Expression is highly reduced in bladder cancer and renal cell carcinoma specimens compared to healthy tissues, but it is increased in other type of tumors. {ECO:0000269|PubMed:23564345}.
Pharmacological Animal Models0.014521(Chimpanzee);0.015233(Mouse);0.001341(Rat);0.021818(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 4Z1F  (X-ray  2.70A  )  4Z1G  (X-ray  3.10A  )  4Z1H  (X-ray  2.90A  )  4Z1I  (X-ray  3.30A  )  5F3K  (X-ray  1.82A  )  5F5R  (X-ray  1.85A  )  5HPH  (X-ray  2.43A  )  5Y3N  (X-ray  2.40A  )  5Y3O  (X-ray  2.70A  )  6XG6  (EM  3.20A  )  7C04  (X-ray  1.70A  )  7C05  (X-ray  2.59A  )  7C7B  (X-ray  1.50A  )  7C7C  (X-ray  3.00A  )  7KCK  (EM  3.26A  )  7KCL  (EM  3.14A  )  7KCM  (EM  3.43A  )  7KLU  (EM  3.50A  )  7KLV  (EM  3.10A  ) 
DBSNP rs13926  rs1136948  rs55766649  rs2791 
Subcellular location [CC]Mitochondrion {ECO:0000269|PubMed:23564345}. Mitochondrion inner membrane {ECO:0000269|PubMed:23564345}. Mitochondrion matrix {ECO:0000269|PubMed:23564345}.
Mouse PG classificationNA
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