| Gene Information | |
|---|---|
| Gene Name | TRAP |
| Organism | Homo sapiens (Human) |
| Gene Length | 261 |
| Protein Names | CD40 ligand (CD40-L) (T-cell antigen Gp39) (TNF-related activation protein) (TRAP) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P29965 |
| Gene Card | CD40LG |
| Uniprot ID | P29965 |
| Pfam | PF00229 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Specifically expressed on activated CD4+ T-lymphocytes. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1ALY (X-ray 2.00A ) 1I9R (X-ray 3.10A ) 3LKJ (X-ray 2.50A ) 3QD6 (X-ray 3.50A ) 6BRB (X-ray 2.82A ) 6W9G (X-ray 1.82A ) 7SGM (X-ray 2.00A ) |
| DBSNP | rs104894774 rs104894778 rs104894777 rs886039326 rs1057521127 rs104894769 rs756468554 rs1569377829 rs148594123 rs104894768 rs104894771 rs193922136 rs1477466218 rs1569377884 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:8626375}; Single-pass type II membrane protein {ECO:0000303|PubMed:8626375}. Cell surface {ECO:0000269|PubMed:15067037, ECO:0000269|PubMed:7678552}.; [CD40 ligand, soluble form]: Secreted {ECO:0000269|PubMed:8626375}. Note=Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and a matrix metalloproteinases (MMP) inhibitor-sensitive pathway. {ECO:0000269|PubMed:15193700}. |
| Mouse PG classification | NA |
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