| Gene Information | |
|---|---|
| Gene Name | TRAM |
| Organism | Homo sapiens (Human) |
| Gene Length | 235 |
| Protein Names | TIR domain-containing adapter molecule 2 (TICAM-2) (Putative NF-kappa-B-activating protein 502) (TRIF-related adapter molecule) (Toll-like receptor adaptor protein 3) (Toll/interleukin-1 receptor domain-containing protein) (MyD88-4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q86XR7 |
| Gene Card | TICAM2 |
| Uniprot ID | Q86XR7 |
| Pfam | PF13676 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas Isoform 2 is ubiquitously expressed (at lower levels than isoform 1). {ECO:0000269|PubMed:12721283, ECO:0000269|PubMed:14519765, ECO:0000269|PubMed:19412184}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2M1W (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:25825441}. Golgi apparatus. Cell membrane {ECO:0000269|PubMed:25825441}. Endoplasmic reticulum. Early endosome membrane. Late endosome membrane. Cell projection, phagocytic cup {ECO:0000269|PubMed:30883606}. Note=Localized to the plasma membrane as a result of myristoylation. Phosphorylation on Ser-16 leads to its depletion from the membrane. Upon LPS stimulation colcoalizes with isoform 2 in late endosomes.; [Isoform 2]: Endoplasmic reticulum. Early endosome membrane. Late endosome membrane. Note=Translocates to late endosomes upon LPS stimulation where it colcoalizes with isoform 1. |
| Mouse PG classification | NA |
| click here to return to the previous page | |